Source:http://linkedlifedata.com/resource/pubmed/id/12431236
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
2002-11-14
|
| pubmed:abstractText |
The performance of memory-guided saccades with two different delays (3 and 30 s of memorization) was studied in seven healthy subjects. Double-pulse transcranial magnetic stimulation (dTMS) with an interstimulus interval of 100 ms was applied over the right dorsolateral prefrontal cortex (DLPFC) early (1 s after target presentation) and late (28 s after target presentation). Early stimulation significantly increased in both delays the percentage of error in amplitude (PEA) of contralateral memory-guided saccades compared to the control experiment without stimulation. dTMS applied late in the delay had no significant effect on PEA. Furthermore, we found a significantly smaller effect of early stimulation in the long-delay paradigm. These results suggest a time-dependent hierarchical organization of the spatial working memory with a functional dominance of DLPFC during the early memorization, independent from the memorization delay. For a long memorization delay, however, working memory seems to have an additional, DLPFC-independent component.
|
| pubmed:language |
eng
|
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:author | |
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1823-7
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:articleTitle |
Time-dependent hierarchical organization of spatial working memory: a transcranial magnetic stimulation study.
|
| pubmed:affiliation |
Eye Movement Research Laboratory, Department of Neurology, Bern University, Bern, CH-3010, Switzerland.
|