| pubmed-article:12429553 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12429553 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:12429553 | lifeskim:mentions | umls-concept:C0227662 | lld:lifeskim |
| pubmed-article:12429553 | lifeskim:mentions | umls-concept:C0020545 | lld:lifeskim |
| pubmed-article:12429553 | lifeskim:mentions | umls-concept:C0387583 | lld:lifeskim |
| pubmed-article:12429553 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:12429553 | pubmed:dateCreated | 2003-1-30 | lld:pubmed |
| pubmed-article:12429553 | pubmed:abstractText | Upregulation of the inducible cyclooxygenase (COX-2) in the macula densa accompanies the activation of the juxtaglomerular apparatus in many high-renin conditions. The functional role of COX-2 in these disease states is poorly understood. We tested whether COX-2 is required to increase renin in renovascular hypertension. Rats with established two-kidney, one-clip (2K1C) hypertension were treated for 2 wk with two different inhibitors of COX-2, NS-398 and rofecoxib, respectively. Hypertension in 2K1C rats was not affected or slightly enhanced by COX-2 inhibition, as measured intra-arterially in conscious animals. The increase in plasma renin activity was also unchanged by both rofecoxib and NS-398. The number of glomeruli with a renin-positive juxtaglomerular apparatus was elevated in clipped kidneys and decreased in contralateral kidneys of 2K1C rats. This pattern was unaltered by COX-2 inhibition. To test the effects of COX-2 blockade on a primarily macula densa-mediated stimulus, we studied salt depletion for comparison. A low-salt diet induced a significant increase in plasma renin activity, which was partially inhibited by treatment with NS-398. We conclude that inhibition of COX-2 in established renovascular hypertension does not affect renin synthesis or release. Thus either COX-2 is not necessary for the macula densa mechanism or the macula densa is not important for maintaining high renin in renovascular hypertension. | lld:pubmed |
| pubmed-article:12429553 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12429553 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12429553 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12429553 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12429553 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12429553 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12429553 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12429553 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12429553 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12429553 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12429553 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12429553 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12429553 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12429553 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12429553 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12429553 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12429553 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12429553 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:12429553 | pubmed:issn | 1931-857X | lld:pubmed |
| pubmed-article:12429553 | pubmed:author | pubmed-author:HilgersKarl... | lld:pubmed |
| pubmed-article:12429553 | pubmed:author | pubmed-author:Goppelt-Strue... | lld:pubmed |
| pubmed-article:12429553 | pubmed:author | pubmed-author:HartnerAndrea... | lld:pubmed |
| pubmed-article:12429553 | pubmed:author | pubmed-author:CordasicNadaN | lld:pubmed |
| pubmed-article:12429553 | pubmed:author | pubmed-author:VeelkenRoland... | lld:pubmed |
| pubmed-article:12429553 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12429553 | pubmed:volume | 284 | lld:pubmed |
| pubmed-article:12429553 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12429553 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12429553 | pubmed:pagination | F498-502 | lld:pubmed |
| pubmed-article:12429553 | pubmed:dateRevised | 2011-4-28 | lld:pubmed |
| pubmed-article:12429553 | pubmed:meshHeading | pubmed-meshheading:12429553... | lld:pubmed |
| pubmed-article:12429553 | pubmed:meshHeading | pubmed-meshheading:12429553... | lld:pubmed |
| pubmed-article:12429553 | pubmed:meshHeading | pubmed-meshheading:12429553... | lld:pubmed |
| pubmed-article:12429553 | pubmed:meshHeading | pubmed-meshheading:12429553... | lld:pubmed |
| pubmed-article:12429553 | pubmed:meshHeading | pubmed-meshheading:12429553... | lld:pubmed |
| pubmed-article:12429553 | pubmed:meshHeading | pubmed-meshheading:12429553... | lld:pubmed |
| pubmed-article:12429553 | pubmed:meshHeading | pubmed-meshheading:12429553... | lld:pubmed |
| pubmed-article:12429553 | pubmed:meshHeading | pubmed-meshheading:12429553... | lld:pubmed |
| pubmed-article:12429553 | pubmed:meshHeading | pubmed-meshheading:12429553... | lld:pubmed |
| pubmed-article:12429553 | pubmed:meshHeading | pubmed-meshheading:12429553... | lld:pubmed |
| pubmed-article:12429553 | pubmed:meshHeading | pubmed-meshheading:12429553... | lld:pubmed |
| pubmed-article:12429553 | pubmed:meshHeading | pubmed-meshheading:12429553... | lld:pubmed |
| pubmed-article:12429553 | pubmed:meshHeading | pubmed-meshheading:12429553... | lld:pubmed |
| pubmed-article:12429553 | pubmed:meshHeading | pubmed-meshheading:12429553... | lld:pubmed |
| pubmed-article:12429553 | pubmed:meshHeading | pubmed-meshheading:12429553... | lld:pubmed |
| pubmed-article:12429553 | pubmed:meshHeading | pubmed-meshheading:12429553... | lld:pubmed |
| pubmed-article:12429553 | pubmed:meshHeading | pubmed-meshheading:12429553... | lld:pubmed |
| pubmed-article:12429553 | pubmed:meshHeading | pubmed-meshheading:12429553... | lld:pubmed |
| pubmed-article:12429553 | pubmed:meshHeading | pubmed-meshheading:12429553... | lld:pubmed |
| pubmed-article:12429553 | pubmed:meshHeading | pubmed-meshheading:12429553... | lld:pubmed |
| pubmed-article:12429553 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12429553 | pubmed:articleTitle | Role of macula densa cyclooxygenase-2 in renovascular hypertension. | lld:pubmed |
| pubmed-article:12429553 | pubmed:affiliation | Department of Medicine IV, University of Erlangen-Nürnberg, 91054 Erlangen, Germany. | lld:pubmed |
| pubmed-article:12429553 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12429553 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:29527 | entrezgene:pubmed | pubmed-article:12429553 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:12429553 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12429553 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12429553 | lld:pubmed |
