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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2003-1-30
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pubmed:abstractText |
Upregulation of the inducible cyclooxygenase (COX-2) in the macula densa accompanies the activation of the juxtaglomerular apparatus in many high-renin conditions. The functional role of COX-2 in these disease states is poorly understood. We tested whether COX-2 is required to increase renin in renovascular hypertension. Rats with established two-kidney, one-clip (2K1C) hypertension were treated for 2 wk with two different inhibitors of COX-2, NS-398 and rofecoxib, respectively. Hypertension in 2K1C rats was not affected or slightly enhanced by COX-2 inhibition, as measured intra-arterially in conscious animals. The increase in plasma renin activity was also unchanged by both rofecoxib and NS-398. The number of glomeruli with a renin-positive juxtaglomerular apparatus was elevated in clipped kidneys and decreased in contralateral kidneys of 2K1C rats. This pattern was unaltered by COX-2 inhibition. To test the effects of COX-2 blockade on a primarily macula densa-mediated stimulus, we studied salt depletion for comparison. A low-salt diet induced a significant increase in plasma renin activity, which was partially inhibited by treatment with NS-398. We conclude that inhibition of COX-2 in established renovascular hypertension does not affect renin synthesis or release. Thus either COX-2 is not necessary for the macula densa mechanism or the macula densa is not important for maintaining high renin in renovascular hypertension.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2 Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Lactones,
http://linkedlifedata.com/resource/pubmed/chemical/N-(2-cyclohexyloxy-4-nitrophenyl)met...,
http://linkedlifedata.com/resource/pubmed/chemical/Nitrobenzenes,
http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandin-Endoperoxide Synthases,
http://linkedlifedata.com/resource/pubmed/chemical/Renin,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium, Dietary,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfonamides,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfones,
http://linkedlifedata.com/resource/pubmed/chemical/rofecoxib
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1931-857X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
284
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
F498-502
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pubmed:dateRevised |
2011-4-28
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pubmed:meshHeading |
pubmed-meshheading:12429553-Animals,
pubmed-meshheading:12429553-Blood Pressure,
pubmed-meshheading:12429553-Cyclooxygenase 2,
pubmed-meshheading:12429553-Cyclooxygenase 2 Inhibitors,
pubmed-meshheading:12429553-Cyclooxygenase Inhibitors,
pubmed-meshheading:12429553-Disease Models, Animal,
pubmed-meshheading:12429553-Hypertension, Renovascular,
pubmed-meshheading:12429553-Immunohistochemistry,
pubmed-meshheading:12429553-Isoenzymes,
pubmed-meshheading:12429553-Lactones,
pubmed-meshheading:12429553-Loop of Henle,
pubmed-meshheading:12429553-Male,
pubmed-meshheading:12429553-Nitrobenzenes,
pubmed-meshheading:12429553-Prostaglandin-Endoperoxide Synthases,
pubmed-meshheading:12429553-Rats,
pubmed-meshheading:12429553-Rats, Sprague-Dawley,
pubmed-meshheading:12429553-Renin,
pubmed-meshheading:12429553-Sodium, Dietary,
pubmed-meshheading:12429553-Sulfonamides,
pubmed-meshheading:12429553-Sulfones
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pubmed:year |
2003
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pubmed:articleTitle |
Role of macula densa cyclooxygenase-2 in renovascular hypertension.
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pubmed:affiliation |
Department of Medicine IV, University of Erlangen-Nürnberg, 91054 Erlangen, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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