Linked Life Data

12429471

Source:http://linkedlifedata.com/resource/pubmed/id/12429471

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2002-11-13
pubmed:abstractText
We report the optimization of polyclonal IgG labeling by 188Re using S-benzoyl-MAG(3) as a model for labeling monoclonal antibodies (MoAb). We examined the in vitro stability of the labeled protein and its localization and excretion in mice with induced focal inflammation. Stability in serum was greater than 85.5% after 24 h. Biodistribution and imaging studies following administration to mice showed mainly renal and hepatic excretion and high IT/NT ratios (4.5 and 4.6) at 24 and 48 h, respectively. This indirect method of labeling antibodies using a 188Re-labeled active ester of MAG(3) produced 188Re-MAG(3)-IgG of high in vitro stability and favorable uptake at sites of focal inflammation.
pubmed:language
eng
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:author
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
173-82
pubmed:dateRevised
2006-11-15
pubmed:articleTitle
Optimization of antibody labeling with rhenium-188 using a prelabeled MAG3 chelate.
pubmed:affiliation
División Radiofármacos, Comisión Nacional de Energia Atómica, Centro Atómico Ezeiza, Pbro. Gonzales y Aragon Num l5, (B1802AYA) Ezeiza, Buenos Aires, Argentina. jlcrudo@cae.cnea.gov.ar