Linked Life Data

12428199

Source:http://linkedlifedata.com/resource/pubmed/id/12428199

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2002-11-12
pubmed:abstractText
The molecular mechanisms of gonadal development are a complex process, which involves the tightly regulated differentiation of a bipotential embryonic gonad into either testes or ovary. Once this has occurred, the phenotypic and gonadal sex of an individual has been genetically determined. This process, however, may not always be so straightforward. By studying individuals who are sex reversed or who have ambiguous genitalia, the discovery of the handful of sex-determining genes that we know of today was made possible. It was not until recently that the transcription factors SRY, DAX1, SOX9, SF-1, and WT1 were recognized to be involved in gonadal development. Dissecting the molecular pathway of mammalian sex determination will be crucial in understanding the development of the gonads and the pathophysiology of human disorders of sex determination.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1526-8004
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
189-98
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Disorders of gonadal development.
pubmed:affiliation
Department of Human Genetics, UCLA School of Medicine, 695 Charles E. Young Drive South, Los Angeles, CA 90095, USA.
pubmed:publicationType
Journal Article, Review