Linked Life Data

12428186

Source:http://linkedlifedata.com/resource/pubmed/id/12428186

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
29-30
pubmed:dateCreated
2002-11-12
pubmed:abstractText
A growing body of evidence suggests that autoimmune responses are involved in the pathogenesis of myocarditis and postinfectious cardiomyopathy. Autoimmunity may also arise after ischaemic or traumatic damage to heart tissue. Myocarditis leading to heart failure can be mimicked in rodents by immunisation with cardiac alpha myosin and peptides derived from it. Cytokines and chemokines, produced mainly by T-cells and antigen-presenting cells, control immune responses by acting as either potentiating or inhibitory agents. Gene targeting and experiments with antibodies and/or antagonists blocking cytokines and their receptors have uncovered mechanisms whereby such regulatory molecules are involved in the pathogenesis of myocarditis. Identification of regulatory key cytokines and the associated pro- or anti-inflammatory pathways involved in the pathogenesis of cardiac inflammation may have important implications for therapeutic strategies and vaccine design in the future.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1424-7860
pubmed:author
pubmed:issnType
Print
pubmed:day
27
pubmed:volume
132
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
408-13
pubmed:dateRevised
2011-2-15
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Cytokines that regulate autoimmune myocarditis.
pubmed:affiliation
Department of Pathology, University Hospital, Zurich, Switzerland.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't