Source:http://linkedlifedata.com/resource/pubmed/id/12428084
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
2002-11-12
|
| pubmed:abstractText |
Venous thrombosis is a multicausal disease involving acquired and genetic factors. In this study we investigated a possible interaction between hyperhomocysteinemia (fasting or postload) and factor V Leiden or prothrombin G20210A on the risk of recurrent venous thrombosis. We also looked at the risk due to mutations in the MTHFR-gene (C677T and A1298C). We performed a case-control study in 171 patients with a history of recurrent venous thrombosis and 461 control subjects from the general population. Hyperhomocysteinemia (fasting or 6 h after an oral methionine load) was defined as a homocysteine concentration above the 90th percentile of the distributions in the control group. The odds ratio (adjusted for age and sex) for recurrent venous thrombosis was 1.8 (95% CI: 1.1 to 3.0) for fasting hyperhomocysteinemia, 5.1 (95% CI: 3.0 to 8.6) for factor V Leiden and 1.8 (95% CI: 0.7 to 4.2) for prothrombin G20210A. We found 14 patients and 3 controls with both hyperhomocysteinemia and factor V Leiden, which yielded an odds ratio of 11.6 (95% CI: 3.2 to 42.5). We found no interaction between hyperhomocysteinemia and prothrombin G20210A. The relative risk for MTHFR 677CT was 1.6 (95% CI: 1.1 to 2.4) and for MTHFR 677TT was 1.4 (95% CI: 0.7 to 2.8). The combined risk for MTHFR 677TT and factor V Leiden was 18.7 (95% CI: 3.3 to 108). We conclude that hyperhomocysteinemia and factor V Leiden are risk factors for recurrent venous thrombosis. The risk of thrombosis appeared high for individuals who had both risk factors.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Factor V,
http://linkedlifedata.com/resource/pubmed/chemical/Methylenetetrahydrofolate...,
http://linkedlifedata.com/resource/pubmed/chemical/Oxidoreductases Acting on CH-NH...,
http://linkedlifedata.com/resource/pubmed/chemical/Prothrombin,
http://linkedlifedata.com/resource/pubmed/chemical/factor V Leiden
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0340-6245
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
88
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
723-8
|
| pubmed:dateRevised |
2005-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:12428084-Adult,
pubmed-meshheading:12428084-Aged,
pubmed-meshheading:12428084-Aged, 80 and over,
pubmed-meshheading:12428084-Case-Control Studies,
pubmed-meshheading:12428084-Factor V,
pubmed-meshheading:12428084-Family Health,
pubmed-meshheading:12428084-Female,
pubmed-meshheading:12428084-Humans,
pubmed-meshheading:12428084-Hyperhomocysteinemia,
pubmed-meshheading:12428084-Male,
pubmed-meshheading:12428084-Methylenetetrahydrofolate Reductase (NADPH2),
pubmed-meshheading:12428084-Middle Aged,
pubmed-meshheading:12428084-Odds Ratio,
pubmed-meshheading:12428084-Oxidoreductases Acting on CH-NH Group Donors,
pubmed-meshheading:12428084-Point Mutation,
pubmed-meshheading:12428084-Prothrombin,
pubmed-meshheading:12428084-Recurrence,
pubmed-meshheading:12428084-Risk Factors,
pubmed-meshheading:12428084-Thrombophilia,
pubmed-meshheading:12428084-Venous Thrombosis
|
| pubmed:year |
2002
|
| pubmed:articleTitle |
Interaction between hyperhomocysteinemia, mutated methylenetetrahydrofolatereductase (MTHFR) and inherited thrombophilic factors in recurrent venous thrombosis.
|
| pubmed:affiliation |
Department of Endocrinology, University Medical Center Nijmegen, 6500 HB Nijmegen, The Netherlands.
|
| pubmed:publicationType |
Journal Article
|