Source:http://linkedlifedata.com/resource/pubmed/id/12427132
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
2002-11-12
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pubmed:abstractText |
There is evidence that mesangial cells express Fcgamma receptors in vitro, but the in vivo relevance of this is not known. FcRgamma-/- mice lack the gamma chain signaling subunit and therefore do not express the activator Fcgamma receptors (FcgammaRI and FcgammaRIII) or the high affinity IgE receptor, FcepsilonRI. FcRgamma-/- mice were protected from renal inflammation following the induction of accelerated nephrotoxic nephritis using sheep anti-mouse glomerular basement membrane anti-serum in mice sensitized to sheep IgG.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0085-2538
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
62
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2087-96
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12427132-Animals,
pubmed-meshheading:12427132-Bone Marrow Transplantation,
pubmed-meshheading:12427132-Chimera,
pubmed-meshheading:12427132-Disease Susceptibility,
pubmed-meshheading:12427132-Glomerular Mesangium,
pubmed-meshheading:12427132-Glomerulonephritis,
pubmed-meshheading:12427132-Leukocytes,
pubmed-meshheading:12427132-Mice,
pubmed-meshheading:12427132-Mice, Inbred C57BL,
pubmed-meshheading:12427132-Mice, Mutant Strains,
pubmed-meshheading:12427132-Receptors, IgG
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pubmed:year |
2002
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pubmed:articleTitle |
Nephrotoxic nephritis is mediated by Fcgamma receptors on circulating leukocytes and not intrinsic renal cells.
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pubmed:affiliation |
Division of Medicine and Department of Histopathology, Imperial College School of Medicine, Hammersmith Hospital, London, England.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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