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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2002-11-12
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pubmed:abstractText |
The matricellular protein SPARC (secreted protein acidic and rich in cysteine) is expressed during development, tissue remodeling and repair. It functions as an endogenous inhibitor of cell proliferation, regulates angiogenesis, regulates cell adhesion to extracellular matrix, binds cytokines such as platelet derived growth factor and stimulates transforming growth factor-beta (TGF-beta) production. This study describes the expression of SPARC during human renal development, in normal kidneys and during renal allograft rejection.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0085-2538
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
62
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2073-86
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12427131-Adult,
pubmed-meshheading:12427131-Antibody Specificity,
pubmed-meshheading:12427131-Chronic Disease,
pubmed-meshheading:12427131-Fetus,
pubmed-meshheading:12427131-Fibroblasts,
pubmed-meshheading:12427131-Fibrosis,
pubmed-meshheading:12427131-Graft Rejection,
pubmed-meshheading:12427131-Humans,
pubmed-meshheading:12427131-Immunohistochemistry,
pubmed-meshheading:12427131-In Situ Hybridization,
pubmed-meshheading:12427131-Kidney,
pubmed-meshheading:12427131-Kidney Transplantation,
pubmed-meshheading:12427131-Myocytes, Smooth Muscle,
pubmed-meshheading:12427131-Osteonectin,
pubmed-meshheading:12427131-RNA, Messenger,
pubmed-meshheading:12427131-Transplantation, Homologous
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pubmed:year |
2002
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pubmed:articleTitle |
Localization of SPARC in developing, mature, and chronically injured human allograft kidneys.
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pubmed:affiliation |
Department of Pathology, University of Washington School of Medicine, Seattle Washington, USA. calp@u.washington.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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