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rdf:type |
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lifeskim:mentions |
|
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pubmed:issue |
5
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pubmed:dateCreated |
2002-11-11
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pubmed:abstractText |
We investigated the effect of polymorphisms in the P-glycoprotein (P-gp) MDR1 gene on steady-state pharmacokinetics of digoxin in Caucasians. According to earlier data, homozygous TT of the exon 26 complementary deoxyribonucleic acid (cDNA) 3435C>T polymorphism was associated with low P-gp expression in the human intestine.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0009-9236
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pubmed:author |
pubmed-author:BrinkmannUlrichU,
pubmed-author:BrockmöllerJürgenJ,
pubmed-author:CascorbiIngolfI,
pubmed-author:EichelbaumMichelM,
pubmed-author:FrommMartin FMF,
pubmed-author:GerloffThomasT,
pubmed-author:HoffmeyerSvenS,
pubmed-author:JohneAndreasA,
pubmed-author:KöpkeKarlaK,
pubmed-author:KerbReinholdR,
pubmed-author:MaiIngridI,
pubmed-author:MeiselChristianC,
pubmed-author:RietbrockStephanS,
pubmed-author:RootsIvarI
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pubmed:issnType |
Print
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pubmed:volume |
72
|
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pubmed:owner |
NLM
|
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pubmed:authorsComplete |
Y
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pubmed:pagination |
584-94
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
|
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pubmed:year |
2002
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pubmed:articleTitle |
Modulation of steady-state kinetics of digoxin by haplotypes of the P-glycoprotein MDR1 gene.
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pubmed:affiliation |
Institute of Clinical Pharmacology, University Medical Center Charité, Humboldt University of Berlin, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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