rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
11
|
pubmed:dateCreated |
2002-11-11
|
pubmed:abstractText |
Studies in mice have shown that genetic disruption of monocyte chemotactic protein-1 or its receptor, the C-C chemokine receptor 2 (CCR2), inhibits atherosclerosis, but few data exist in humans to suggest that the monocyte chemotactic protein-1-CCR2 interaction is important in atherogenesis. A common polymorphism in the human CCR2 gene resulting in a substitution of isoleucine for valine (Val64Ile) has been associated with other disease phenotypes in humans.
|
pubmed:grant |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Nov
|
pubmed:issn |
1524-4636
|
pubmed:author |
|
pubmed:issnType |
Electronic
|
pubmed:day |
1
|
pubmed:volume |
22
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1924-8
|
pubmed:dateRevised |
2007-11-15
|
pubmed:meshHeading |
pubmed-meshheading:12426226-Adult,
pubmed-meshheading:12426226-Aged,
pubmed-meshheading:12426226-Amino Acid Substitution,
pubmed-meshheading:12426226-Calcinosis,
pubmed-meshheading:12426226-Cardiomyopathies,
pubmed-meshheading:12426226-Coronary Vessels,
pubmed-meshheading:12426226-Female,
pubmed-meshheading:12426226-Genotype,
pubmed-meshheading:12426226-Humans,
pubmed-meshheading:12426226-Isoleucine,
pubmed-meshheading:12426226-Male,
pubmed-meshheading:12426226-Middle Aged,
pubmed-meshheading:12426226-Models, Statistical,
pubmed-meshheading:12426226-Polymorphism, Genetic,
pubmed-meshheading:12426226-Receptors, CCR2,
pubmed-meshheading:12426226-Receptors, Chemokine,
pubmed-meshheading:12426226-Sex Factors,
pubmed-meshheading:12426226-Valine
|
pubmed:year |
2002
|
pubmed:articleTitle |
Val64Ile polymorphism in the C-C chemokine receptor 2 is associated with reduced coronary artery calcification.
|
pubmed:affiliation |
GlaxoSmithKline, Stevenage, Hertfordshire, UK.
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|