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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2002-11-11
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pubmed:abstractText |
We have previously reported that products of the lipoxygenase pathway, hydroperoxyoctadecadienoic acid and hydroperoxyeicosatetraenoic acid, as well as cholesterol linoleate hydroperoxides, collectively termed seeding molecules, are removed by apolipoprotein A-I (apoA-I) from the artery wall cells and render low density lipoprotein (LDL) resistant to oxidation by human artery wall cells. The mechanisms by which oxidized lipids are transported and/or transferred to lipoproteins and the pathways by which apoA-I facilitates their removal remain unclear. ATP-binding cassette transporter 1 (ABCA1) is known to facilitate the release of cellular phospholipids and cholesterol from the plasma membrane to apoA-I and high density lipoprotein. Therefore, we evaluated whether ABCA1 participates in LDL oxidation.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/22-hydroxycholesterol,
http://linkedlifedata.com/resource/pubmed/chemical/4,4'-Diisothiocyanostilbene-2,2'-Dis...,
http://linkedlifedata.com/resource/pubmed/chemical/ATP binding cassette transporter 1,
http://linkedlifedata.com/resource/pubmed/chemical/ATP-Binding Cassette Transporters,
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoprotein A-I,
http://linkedlifedata.com/resource/pubmed/chemical/Glyburide,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxycholesterols,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins, LDL,
http://linkedlifedata.com/resource/pubmed/chemical/Oligonucleotides, Antisense,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Reactive Oxygen Species,
http://linkedlifedata.com/resource/pubmed/chemical/oxidized low density lipoprotein
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1524-4636
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1877-83
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12426219-4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid,
pubmed-meshheading:12426219-ATP-Binding Cassette Transporters,
pubmed-meshheading:12426219-Aorta,
pubmed-meshheading:12426219-Apolipoprotein A-I,
pubmed-meshheading:12426219-Arteries,
pubmed-meshheading:12426219-Cells, Cultured,
pubmed-meshheading:12426219-Endothelium, Vascular,
pubmed-meshheading:12426219-Glyburide,
pubmed-meshheading:12426219-Humans,
pubmed-meshheading:12426219-Hydroxycholesterols,
pubmed-meshheading:12426219-Lipoproteins, LDL,
pubmed-meshheading:12426219-Muscle, Smooth, Vascular,
pubmed-meshheading:12426219-Oligonucleotides, Antisense,
pubmed-meshheading:12426219-Oxidation-Reduction,
pubmed-meshheading:12426219-RNA, Messenger,
pubmed-meshheading:12426219-Reactive Oxygen Species
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pubmed:year |
2002
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pubmed:articleTitle |
ATP-binding cassette transporter 1 participates in LDL oxidation by artery wall cells.
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pubmed:affiliation |
Atherosclerosis Research Unit, Division of Cardiology, Department of Medicine, University of California, Los Angeles 90095, USA. sreddy@mednet.ucla.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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