| pubmed-article:12423758 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12423758 | lifeskim:mentions | umls-concept:C0020971 | lld:lifeskim |
| pubmed-article:12423758 | lifeskim:mentions | umls-concept:C0004611 | lld:lifeskim |
| pubmed-article:12423758 | lifeskim:mentions | umls-concept:C0018894 | lld:lifeskim |
| pubmed-article:12423758 | lifeskim:mentions | umls-concept:C0080202 | lld:lifeskim |
| pubmed-article:12423758 | lifeskim:mentions | umls-concept:C0012854 | lld:lifeskim |
| pubmed-article:12423758 | lifeskim:mentions | umls-concept:C0178719 | lld:lifeskim |
| pubmed-article:12423758 | lifeskim:mentions | umls-concept:C0282580 | lld:lifeskim |
| pubmed-article:12423758 | lifeskim:mentions | umls-concept:C0020964 | lld:lifeskim |
| pubmed-article:12423758 | lifeskim:mentions | umls-concept:C0205369 | lld:lifeskim |
| pubmed-article:12423758 | lifeskim:mentions | umls-concept:C0599894 | lld:lifeskim |
| pubmed-article:12423758 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:12423758 | lifeskim:mentions | umls-concept:C0728938 | lld:lifeskim |
| pubmed-article:12423758 | lifeskim:mentions | umls-concept:C0205171 | lld:lifeskim |
| pubmed-article:12423758 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:12423758 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:12423758 | pubmed:dateCreated | 2002-11-8 | lld:pubmed |
| pubmed-article:12423758 | pubmed:abstractText | We evaluated here the effect of the intracellular targeting of a helper T-cell (Th) epitope, literiolysin O 215-226 derived from Listeria monocytogenes, on induction of a specific Th by gene gun immunisation. Immunisation of C3H/He mice with pE215LAMP plasmid encoding the Th epitope fused with the endosomal/lysosomal targeting signal of lysosome-associated membrane protein (LAMP)-1 gave the epitope-specific proliferative responses of CD4(+) T lymphocytes. In addition, specific interferon-gamma production from the splenocytes was observed. Concomitantly, pE215LAMP-immunised mice showed moderate, but significant protective immunity against listerial challenge. These results suggest that the intracellular targeting of a Th epitope to endosomal/lysosomal compartments by DNA immunisation is useful for eliciting a specific Th subset in vivo. | lld:pubmed |
| pubmed-article:12423758 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12423758 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12423758 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12423758 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12423758 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12423758 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12423758 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12423758 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12423758 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12423758 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12423758 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12423758 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12423758 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12423758 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:12423758 | pubmed:issn | 0378-1097 | lld:pubmed |
| pubmed-article:12423758 | pubmed:author | pubmed-author:YamadaTakashi... | lld:pubmed |
| pubmed-article:12423758 | pubmed:author | pubmed-author:NakamuraHirot... | lld:pubmed |
| pubmed-article:12423758 | pubmed:author | pubmed-author:NagataToshiT | lld:pubmed |
| pubmed-article:12423758 | pubmed:author | pubmed-author:AoshiTaikiT | lld:pubmed |
| pubmed-article:12423758 | pubmed:author | pubmed-author:UchijimaMasat... | lld:pubmed |
| pubmed-article:12423758 | pubmed:author | pubmed-author:KoideYukioY | lld:pubmed |
| pubmed-article:12423758 | pubmed:author | pubmed-author:ChidaKingoK | lld:pubmed |
| pubmed-article:12423758 | pubmed:author | pubmed-author:SudaTakafumiT | lld:pubmed |
| pubmed-article:12423758 | pubmed:author | pubmed-author:UchiyamaHiros... | lld:pubmed |
| pubmed-article:12423758 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12423758 | pubmed:day | 29 | lld:pubmed |
| pubmed-article:12423758 | pubmed:volume | 216 | lld:pubmed |
| pubmed-article:12423758 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12423758 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12423758 | pubmed:pagination | 91-7 | lld:pubmed |
| pubmed-article:12423758 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:12423758 | pubmed:meshHeading | pubmed-meshheading:12423758... | lld:pubmed |
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| pubmed-article:12423758 | pubmed:meshHeading | pubmed-meshheading:12423758... | lld:pubmed |
| pubmed-article:12423758 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12423758 | pubmed:articleTitle | Endosomal/lysosomal targeting of a single helper T-cell epitope of an intracellular bacterium by DNA immunisation induces a specific T-cell subset and partial protective immunity in vivo. | lld:pubmed |
| pubmed-article:12423758 | pubmed:affiliation | Second Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan. | lld:pubmed |
| pubmed-article:12423758 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12423758 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
