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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2003-10-29
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pubmed:abstractText |
Results from numerous studies point convincingly to correlations between mutations at selected genes and phenotypic resistance to antimalarials in Plasmodium falciparum isolates. In order to move molecular assays for point mutations on resistance-related genes into the realm of applied tools for surveillance, we investigated a selection of P. falciparum isolates that were imported during the year 2001 into Europe to study the prevalence of resistance-associated point mutations at relevant codons. In particular, we tested for parasites which were developing resistance to antifolates and chloroquine. The screening results were used to map the prevalence of mutations and, thus, levels of potential drug resistance in endemic areas world-wide.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/12423552-10432069,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12423552-10747279,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12423552-10885831,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12423552-11090624,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12423552-11172152,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12423552-11517439,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12423552-11703841,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12423552-11803507,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12423552-11807721,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12423552-8203301,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12423552-9015515,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12423552-9025692,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12423552-9075340,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12423552-9593041,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12423552-9603482,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12423552-9735930
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ATP-Binding Cassette Transporters,
http://linkedlifedata.com/resource/pubmed/chemical/Antimalarials,
http://linkedlifedata.com/resource/pubmed/chemical/Chloroquine,
http://linkedlifedata.com/resource/pubmed/chemical/Codon,
http://linkedlifedata.com/resource/pubmed/chemical/Dihydropteroate Synthase,
http://linkedlifedata.com/resource/pubmed/chemical/Folic Acid Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Transport Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/PfCRT protein, Plasmodium falciparum,
http://linkedlifedata.com/resource/pubmed/chemical/Protozoan Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Tetrahydrofolate Dehydrogenase,
http://linkedlifedata.com/resource/pubmed/chemical/mdr gene protein, Plasmodium
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1475-2875
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pubmed:author |
pubmed-author:AlifrangisMichaelM,
pubmed-author:BeranJiriJ,
pubmed-author:BurchardGerdG,
pubmed-author:CuadrosJuanJ,
pubmed-author:GasconJoaquimJ,
pubmed-author:GjørupIdaI,
pubmed-author:GrobuschMartin PMP,
pubmed-author:HatzChristophC,
pubmed-author:JelinekTomasT,
pubmed-author:KernPeterP,
pubmed-author:KollaritschHerwigH,
pubmed-author:LaferlHermannH,
pubmed-author:MühlbergerNikolaiN,
pubmed-author:McWhinneyPaulP,
pubmed-author:Peyerl-HoffmannGabrieleG,
pubmed-author:SchmiderNadjaN,
pubmed-author:SchulzeMarcoM,
pubmed-author:WichmannOleO,
pubmed-author:WilhelmMichaelM,
pubmed-author:da CunhaSaraivaS,
pubmed-author:von SonnenburgFrankF
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pubmed:issnType |
Electronic
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pubmed:day |
11
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pubmed:volume |
1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
11
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pubmed:dateRevised |
2010-9-14
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pubmed:meshHeading |
pubmed-meshheading:12423552-ATP-Binding Cassette Transporters,
pubmed-meshheading:12423552-Animals,
pubmed-meshheading:12423552-Antimalarials,
pubmed-meshheading:12423552-Chloroquine,
pubmed-meshheading:12423552-Codon,
pubmed-meshheading:12423552-Dihydropteroate Synthase,
pubmed-meshheading:12423552-Drug Resistance,
pubmed-meshheading:12423552-Drug Resistance, Multiple,
pubmed-meshheading:12423552-Europe,
pubmed-meshheading:12423552-Folic Acid Antagonists,
pubmed-meshheading:12423552-Humans,
pubmed-meshheading:12423552-Malaria, Falciparum,
pubmed-meshheading:12423552-Membrane Proteins,
pubmed-meshheading:12423552-Membrane Transport Proteins,
pubmed-meshheading:12423552-Plasmodium falciparum,
pubmed-meshheading:12423552-Point Mutation,
pubmed-meshheading:12423552-Protozoan Proteins,
pubmed-meshheading:12423552-Tetrahydrofolate Dehydrogenase,
pubmed-meshheading:12423552-Travel
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pubmed:year |
2002
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pubmed:articleTitle |
Molecular surveillance of drug resistance through imported isolates of Plasmodium falciparum in Europe.
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pubmed:affiliation |
Department of Infectious Diseases and Tropical Medicine, University of Munich, Leopoldstr, 5, 80802 Munich, Germany. jelinek@lrz.uni-muenchen.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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