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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2002-11-7
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pubmed:abstractText |
Inflammation and elastinolysis are observed in the media of abdominal aortic aneurysms (AAAs) where vascular smooth muscle cell (VSMC) density is decreased. In contrast, elastin and VSMCs are preserved in the noninflammatory media of stenotic atherosclerotic lesions. We have tested the hypothesis that VSMCs exert a protective effect against inflammation and proteolysis in a model of AAA in rats, in which medial elastin degradation is driven by inflammation and matrix metalloproteinases.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0741-5214
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
36
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1018-26
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12422114-Animals,
pubmed-meshheading:12422114-Aorta, Abdominal,
pubmed-meshheading:12422114-Aortic Aneurysm, Abdominal,
pubmed-meshheading:12422114-Elastin,
pubmed-meshheading:12422114-Guinea Pigs,
pubmed-meshheading:12422114-Inflammation,
pubmed-meshheading:12422114-Male,
pubmed-meshheading:12422114-Matrix Metalloproteinases,
pubmed-meshheading:12422114-Muscle, Smooth, Vascular,
pubmed-meshheading:12422114-Protease Inhibitors,
pubmed-meshheading:12422114-RNA, Messenger,
pubmed-meshheading:12422114-Rats,
pubmed-meshheading:12422114-Rats, Inbred F344,
pubmed-meshheading:12422114-Tissue Inhibitor of Metalloproteinases,
pubmed-meshheading:12422114-Transplantation, Heterologous
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pubmed:year |
2002
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pubmed:articleTitle |
Paracrine effect of vascular smooth muscle cells in the prevention of aortic aneurysm formation.
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pubmed:affiliation |
CNRS UMR-A 7054, Centre de Recherches Chirurgicales, Créteil, France. allaire@lub-internet.fr
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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