| pubmed-article:12421963 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12421963 | lifeskim:mentions | umls-concept:C0319941 | lld:lifeskim |
| pubmed-article:12421963 | lifeskim:mentions | umls-concept:C0330390 | lld:lifeskim |
| pubmed-article:12421963 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:12421963 | lifeskim:mentions | umls-concept:C0109272 | lld:lifeskim |
| pubmed-article:12421963 | lifeskim:mentions | umls-concept:C0301872 | lld:lifeskim |
| pubmed-article:12421963 | lifeskim:mentions | umls-concept:C0282498 | lld:lifeskim |
| pubmed-article:12421963 | lifeskim:mentions | umls-concept:C1515021 | lld:lifeskim |
| pubmed-article:12421963 | lifeskim:mentions | umls-concept:C0127400 | lld:lifeskim |
| pubmed-article:12421963 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:12421963 | pubmed:dateCreated | 2002-11-7 | lld:pubmed |
| pubmed-article:12421963 | pubmed:abstractText | Immunization with recombinant heat shock protein 60 (rHsp60) from Histoplasma capsulatum or a region of the protein designated fragment 3 (F3) confers protection from a subsequent challenge in mice. To determine the T cell repertoire involved in the response to Hsp60, T cell clones from C57BL/6 mice immunized with rHsp60 were generated and examined for Vbeta usage by flow cytometry and RT-PCR. Vbeta8.1/8.2(+) T cells were preferentially expanded; other clones bore Vbeta4, -6, or -11. When Vbeta8.1/8.2(+) cells were depleted in mice, Vbeta4(+) T cell clones were almost exclusively isolated. Measurement of cytokine production demonstrated that nine of 16 Vbeta8.1/8.2(+) clones were Th1, while only three of 13 non-Vbeta8.1/8.2(+) clones were Th1. In mice immunized with rHsp60, depletion of Vbeta8.1/8.2(+), but not Vbeta6(+) plus Vbeta7(+), T cells completely abolished the protective efficacy of Hsp60 to lethal and sublethal challenges. Examination of the TCR revealed that a subset of Vbeta8.1/2(+) clones that produced IFN-gamma and were reactive to F3 shared a common CDR3 sequence, DGGQG. Transfer of these T cell clones into TCR alpha/beta(-/-) or IFN-gamma(-/-) mice significantly improved survival, while transfer of other Vbeta8.1/8.2(+) clones that were F3 reactive but were Th2 or clones that were not reactive to F3 but were Th1 did not confer protection. These data indicate that a distinct subset of Vbeta8.1/8.2(+) T cells is crucial for the generation of a protective response to rHsp60. | lld:pubmed |
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| pubmed-article:12421963 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12421963 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12421963 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:12421963 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12421963 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:12421963 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:12421963 | pubmed:author | pubmed-author:DeepeGeorge... | lld:pubmed |
| pubmed-article:12421963 | pubmed:author | pubmed-author:ScheckelhoffM... | lld:pubmed |
| pubmed-article:12421963 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12421963 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:12421963 | pubmed:volume | 169 | lld:pubmed |
| pubmed-article:12421963 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12421963 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12421963 | pubmed:pagination | 5818-26 | lld:pubmed |
| pubmed-article:12421963 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:12421963 | pubmed:meshHeading | pubmed-meshheading:12421963... | lld:pubmed |
| pubmed-article:12421963 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12421963 | pubmed:articleTitle | The protective immune response to heat shock protein 60 of Histoplasma capsulatum is mediated by a subset of V beta 8.1/8.2+ T cells. | lld:pubmed |
| pubmed-article:12421963 | pubmed:affiliation | Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA. | lld:pubmed |
| pubmed-article:12421963 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12421963 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12421963 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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