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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2002-11-7
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pubmed:abstractText |
Lymphocyte activation gene (LAG)-3 (CD223) is a CD4-related activation-induced cell surface molecule that binds to MHC class II molecules with high affinity and negatively regulates T cell expansion and homeostasis. In this study, we show that LAG-3 inhibits CD4-dependent, but not CD4-independent, T cell function via its cytoplasmic domain. Although high affinity interaction with MHC class II molecules is essential for LAG-3 function, tailless LAG-3 does not compete with CD4 for ligand binding. A single lysine residue (K468) within a conserved "KIEELE" motif is essential for interaction with downstream signaling molecules. These data provide insight into the mechanism of action of this important T cell regulatory molecule.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
169
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5392-5
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12421911-Amino Acid Motifs,
pubmed-meshheading:12421911-Amino Acid Sequence,
pubmed-meshheading:12421911-Animals,
pubmed-meshheading:12421911-Antigens, CD,
pubmed-meshheading:12421911-Antigens, CD4,
pubmed-meshheading:12421911-Conserved Sequence,
pubmed-meshheading:12421911-Cytoplasm,
pubmed-meshheading:12421911-Down-Regulation,
pubmed-meshheading:12421911-Histocompatibility Antigens Class II,
pubmed-meshheading:12421911-Humans,
pubmed-meshheading:12421911-Hybridomas,
pubmed-meshheading:12421911-Ligands,
pubmed-meshheading:12421911-Lymphocyte Activation,
pubmed-meshheading:12421911-Membrane Proteins,
pubmed-meshheading:12421911-Mice,
pubmed-meshheading:12421911-Molecular Sequence Data,
pubmed-meshheading:12421911-Protein Structure, Tertiary,
pubmed-meshheading:12421911-Tumor Cells, Cultured
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pubmed:year |
2002
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pubmed:articleTitle |
Cutting edge: molecular analysis of the negative regulatory function of lymphocyte activation gene-3.
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pubmed:affiliation |
Department of Immunology, St. Jude Children's Research Hospital, 332 West Lauderdale, Memphis, TN 38105, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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