Source:http://linkedlifedata.com/resource/pubmed/id/12419777
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2003-1-30
|
| pubmed:abstractText |
Deregulation of the inflammatory response plays a major role in the age-related decline of physical performance. The causal pathway leading from inflammation to disability has not been fully clarified, but several researches suggest that interleukin-6 (IL-6) causes a reduction of physical performance in elderly through its effect on muscle function. In vitro studies demonstrated that IL-6 inhibits the secretion of insulin-like growth factor I (IGF-I) and its biological activity, suggesting that the negative effect of IL-6 on muscle function might be mediated through IGF-I. We evaluated the joint effect of IGF-I and IL-6 on muscle function in a population-based sample of 526 persons with a wide age range (20-102 yr). After adjusting for potential confounders, such as age, sex, body mass index, IL-6 receptor, and IL-6 promoter polymorphism, IL-6, IGF-I, and their interaction were significant predictors of handgrip and muscle power. In analyses stratified by IL-6 tertiles, IGF-I was an independent predictor of muscle function only in subjects in the lowest IL-6 tertile, suggesting that the effect of IGF-I on muscle function depends on IL-6 levels. This mechanism may explain why IL-6 is a strong risk factor for disability.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0193-1849
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| pubmed:author |
pubmed-author:BandinelliStefaniaS,
pubmed-author:BarbieriMichelangelaM,
pubmed-author:BonafèMassimilianoM,
pubmed-author:CorsiAnnamariaA,
pubmed-author:FerrucciLuigiL,
pubmed-author:FranceschiClaudioC,
pubmed-author:GiovagnettiSimonaS,
pubmed-author:GuralnikJack MJM,
pubmed-author:OlivieriFabiolaF,
pubmed-author:PaolissoGiuseppeG,
pubmed-author:RagnoEmiliaE
|
| pubmed:issnType |
Print
|
| pubmed:volume |
284
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
E481-7
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:12419777-Adult,
pubmed-meshheading:12419777-Aged,
pubmed-meshheading:12419777-Aged, 80 and over,
pubmed-meshheading:12419777-Aging,
pubmed-meshheading:12419777-Chronic Disease,
pubmed-meshheading:12419777-Female,
pubmed-meshheading:12419777-Hand Strength,
pubmed-meshheading:12419777-Humans,
pubmed-meshheading:12419777-Inflammation,
pubmed-meshheading:12419777-Insulin-Like Growth Factor I,
pubmed-meshheading:12419777-Interleukin-6,
pubmed-meshheading:12419777-Male,
pubmed-meshheading:12419777-Middle Aged,
pubmed-meshheading:12419777-Muscle, Skeletal,
pubmed-meshheading:12419777-Prospective Studies
|
| pubmed:year |
2003
|
| pubmed:articleTitle |
Chronic inflammation and the effect of IGF-I on muscle strength and power in older persons.
|
| pubmed:affiliation |
Department of Geriatric Medicine and Metabolic Diseases, II University of Naples, Italy.
|
| pubmed:publicationType |
Journal Article
|