Source:http://linkedlifedata.com/resource/pubmed/id/12419375
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
23
|
| pubmed:dateCreated |
2002-11-6
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| pubmed:abstractText |
Optimized substituent patterns in 4-aryl-pyridine glucagon receptor antagonists were merged to produce highly potent derivatives containing both a 3-[(1R)-hydroxyethyl] and a 2'-hydroxy group. Due to restricted rotation of the phenyl-pyridine bond, these analogues exist as four isomers. A diastereoselective methylcopper reaction was developed to facilitate the synthesis, and single isomers were isolated with activities in the range IC(50)=10-25 nM.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Dec
|
| pubmed:issn |
0960-894X
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| pubmed:author |
pubmed-author:CookJames HJH,
pubmed-author:HertzogDonald LDL,
pubmed-author:HundertmarkThomasT,
pubmed-author:JonesJ HowardJH,
pubmed-author:KorpusikMaryM,
pubmed-author:LadouceurGaetan HGH,
pubmed-author:LeaseTimothy GTG,
pubmed-author:LivingstonJames NJN,
pubmed-author:MacDougallMargit LML,
pubmed-author:OsterhoutMartin HMH,
pubmed-author:PhelanKathleenK,
pubmed-author:RomeroRomulo HRH,
pubmed-author:SchoenWilliam RWR,
pubmed-author:ShaoChunningC,
pubmed-author:SmithRoger ARA
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| pubmed:issnType |
Print
|
| pubmed:day |
2
|
| pubmed:volume |
12
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
3421-4
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| pubmed:meshHeading | |
| pubmed:year |
2002
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| pubmed:articleTitle |
Integration of optimized substituent patterns to produce highly potent 4-aryl-pyridine glucagon receptor antagonists.
|
| pubmed:affiliation |
Department of Chemistry Research, Bayer Research Center, West Haven, CT 06516, USA. gaetan.ladouceur.b@bayer.com
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| pubmed:publicationType |
Journal Article
|