Source:http://linkedlifedata.com/resource/pubmed/id/12419367
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
23
|
| pubmed:dateCreated |
2002-11-6
|
| pubmed:abstractText |
Two new compounds, 8-(1,1-dimethylallyl)-5'-(3-methylbut-2-enyl)-3',4',5,7-tetrahydroxyflanvonol (1), 3'-(3-methylbut-2-enyl)-3',4',7-trihydroxyflavane (2) and three known compounds 3,3',4',5,7-pentahydroxyflavone (3), uralenol (4), broussochalcone A (5) were isolated from the roots of Broussonetia papyrifera, and their structures determined by spectroscopic methods. Compounds 1, 3, 4 and 5 significantly show the inhibitory activities against the PTP1B enzyme.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0960-894X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
2
|
| pubmed:volume |
12
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
3387-90
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:12419367-Enzyme Inhibitors,
pubmed-meshheading:12419367-Flavonoids,
pubmed-meshheading:12419367-Inhibitory Concentration 50,
pubmed-meshheading:12419367-Nuclear Magnetic Resonance, Biomolecular,
pubmed-meshheading:12419367-Plant Roots,
pubmed-meshheading:12419367-Plants, Medicinal,
pubmed-meshheading:12419367-Protein Tyrosine Phosphatase, Non-Receptor Type 1,
pubmed-meshheading:12419367-Protein Tyrosine Phosphatases,
pubmed-meshheading:12419367-Rosales
|
| pubmed:year |
2002
|
| pubmed:articleTitle |
Natural PTP1B inhibitors from Broussonetia papyrifera.
|
| pubmed:affiliation |
Chinese National Center for Drug Screening, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|