|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
23
|
|
pubmed:dateCreated |
2002-11-6
|
|
pubmed:abstractText |
The ribosomal decoding site is the target of aminoglycoside antibiotics that specifically recognize an internal loop RNA structure. We synthesized RNA-targeted 2,5-dideoxystreptamine-4-amides in which a sugar moiety in natural aminoglycosides is replaced by heterocycles.
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|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
0960-894X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
2
|
|
pubmed:volume |
12
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
3367-72
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:12419363-Aminoglycosides,
pubmed-meshheading:12419363-Anti-Bacterial Agents,
pubmed-meshheading:12419363-Binding Sites,
pubmed-meshheading:12419363-Hexosamines,
pubmed-meshheading:12419363-Luciferases,
pubmed-meshheading:12419363-Models, Molecular,
pubmed-meshheading:12419363-Protein Biosynthesis,
pubmed-meshheading:12419363-RNA, Ribosomal,
pubmed-meshheading:12419363-Structure-Activity Relationship,
pubmed-meshheading:12419363-Transcription, Genetic
|
|
pubmed:year |
2002
|
|
pubmed:articleTitle |
Novel 2,5-dideoxystreptamine derivatives targeting the ribosomal decoding site RNA.
|
|
pubmed:affiliation |
Department of Medicinal Chemistry, Anadys Pharmaceuticals, Inc., San Diego, CA 92121, USA. dvourloumis@anadyspharma.com
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|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|
