Linked Life Data

12418883

Source:http://linkedlifedata.com/resource/pubmed/id/12418883

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
45
pubmed:dateCreated
2002-11-6
pubmed:abstractText
Bicontinuous cubic phases of monoacylglycerides/Poloxamer 407 (PEO98PPO67PEO98)/water can be dispersed into submicron particles, which are termed "cubosomes". Technological applications of these nanoparticles may be possible, if their nonlamellar architecture can be rendered more robust. To accomplish this goal, a polymerizable heterobifunctional monoacylglycerol, 3-(2,4,13-(E,E)-tetradecatrienoyl)-sn-glycerol (1), was synthesized and combined with water to form an optically transparent gel. In the presence of Poloxamer 407 and excess water the cubic phase of 1 was dispersed by ultrasonication into 300-nm diameter nanoparticles. The polymerization of these reactive cubosomes could be initiated either by the use of a photoinitiator or with redox chemistry. The polymerized cubosomes remained stable even after the addition of excess Triton X-100, in a manner consistent with executing cross-linking in the nanostructures.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0002-7863
pubmed:author
pubmed:issnType
Print
pubmed:day
13
pubmed:volume
124
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
13388-9
pubmed:dateRevised
2008-1-17
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Polymerized bicontinuous cubic nanoparticles (cubosomes) from a reactive monoacylglycerol.
pubmed:affiliation
C. S. Marvel Laboratories, Department of Chemistry, University of Arizona, Tucson 85721, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.