Linked Life Data

12418880

Source:http://linkedlifedata.com/resource/pubmed/id/12418880

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pubmed-article:12418880pubmed:abstractTextMolecular transporters have the ability to deliver drugs and probe molecules into cells and tissues irrespective of their physical properties. We now report the design, synthesis, and biological evaluation of a new family of molecular transporters, guanidinylated oligocarbamates that enable exceptionally efficient uptake into cells and tissues. The synthesis features a solid-phase stepwise oligomerization to obtain the oligocarbamates and a single step perguanidinylation for the facile introduction of up to nine guanidinium groups. The oligocarbamate 9-mer is found to be among the most efficient transporters known, entering cells faster than even d-Arg9 and HIV-1 Tat49-57. Significantly, this new family of transporters also enables uptake into the formidable skin barrier of a probe molecule that by itself does not penetrate skin.lld:pubmed
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pubmed-article:12418880pubmed:dateRevised2008-1-17lld:pubmed
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pubmed-article:12418880pubmed:articleTitleOligocarbamate molecular transporters: design, synthesis, and biological evaluation of a new class of transporters for drug delivery.lld:pubmed
pubmed-article:12418880pubmed:affiliationDepartment of Chemistry, Stanford University, California 94305-5080, USA. wenderp@stanford.edulld:pubmed
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