|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
2002-11-5
|
|
pubmed:abstractText |
Several genomic regions have been identified that might contain genes contributing to the development of asthma and atopy. These include chromosome 2q33, where we have observed evidence for linkage for variation in total serum IgE levels in a Dutch asthma population. Two candidate genes, CTLA4 and CD28, important homeostatic regulators of T-cell activation and subsequent IgE production, map within this candidate region.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD28,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation,
http://linkedlifedata.com/resource/pubmed/chemical/CTLA-4 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/CTLA4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoconjugates,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin E,
http://linkedlifedata.com/resource/pubmed/chemical/abatacept
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
0091-6749
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
110
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
743-51
|
|
pubmed:dateRevised |
2011-11-17
|
|
pubmed:meshHeading |
pubmed-meshheading:12417883-Antigens, CD,
pubmed-meshheading:12417883-Antigens, CD28,
pubmed-meshheading:12417883-Antigens, Differentiation,
pubmed-meshheading:12417883-Asthma,
pubmed-meshheading:12417883-Bronchial Hyperreactivity,
pubmed-meshheading:12417883-CTLA-4 Antigen,
pubmed-meshheading:12417883-Chromosome Mapping,
pubmed-meshheading:12417883-Chromosomes, Human, Pair 2,
pubmed-meshheading:12417883-Female,
pubmed-meshheading:12417883-Gene Frequency,
pubmed-meshheading:12417883-Genetic Linkage,
pubmed-meshheading:12417883-Genotype,
pubmed-meshheading:12417883-Humans,
pubmed-meshheading:12417883-Immunoconjugates,
pubmed-meshheading:12417883-Immunoglobulin E,
pubmed-meshheading:12417883-Male,
pubmed-meshheading:12417883-Middle Aged,
pubmed-meshheading:12417883-Phenotype,
pubmed-meshheading:12417883-Polymorphism, Single Nucleotide,
pubmed-meshheading:12417883-Promoter Regions, Genetic,
pubmed-meshheading:12417883-Transcriptional Activation
|
|
pubmed:year |
2002
|
|
pubmed:articleTitle |
Fine mapping of an IgE-controlling gene on chromosome 2q: Analysis of CTLA4 and CD28.
|
|
pubmed:affiliation |
Center for Human Genomics, Department of Pediatrics, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
