Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
23
pubmed:dateCreated
2002-11-5
pubmed:abstractText
The PEX11 peroxisomal membrane proteins promote peroxisome division in multiple eukaryotes. As part of our effort to understand the molecular and physiological functions of PEX11 proteins, we disrupted the mouse PEX11alpha gene. Overexpression of PEX11alpha is sufficient to promote peroxisome division, and a class of chemicals known as peroxisome proliferating agents (PPAs) induce the expression of PEX11alpha and promote peroxisome division. These observations led to the hypothesis that PPAs induce peroxisome abundance by enhancing PEX11alpha expression. The phenotypes of PEX11alpha(-/-) mice indicate that this hypothesis remains valid for a novel class of PPAs that act independently of peroxisome proliferator-activated receptor alpha (PPARalpha) but is not valid for the classical PPAs that act as activators of PPARalpha. Furthermore, we find that PEX11alpha(-/-) mice have normal peroxisome abundance and that cells lacking both PEX11alpha and PEX11beta, a second mammalian PEX11 gene, have no greater defect in peroxisome abundance than do cells lacking only PEX11beta. Finally, we report the identification of a third mammalian PEX11 gene, PEX11gamma, and show that it too encodes a peroxisomal protein.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/12417726-10212151, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417726-10527683, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417726-10716247, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417726-10871277, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417726-10931862, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417726-10966461, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417726-11068037, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417726-11092841, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417726-11252894, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417726-11260462, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417726-11356164, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417726-11375435, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417726-11493655, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417726-11564741, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417726-11592822, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417726-11733545, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417726-11792861, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417726-11818483, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417726-11839773, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417726-12024045, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417726-12067588, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417726-1438384, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417726-1654856, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417726-2231712, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417726-3915782, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417726-4047762, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417726-4186511, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417726-7544797, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417726-7550347, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417726-7592467, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417726-7721939, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417726-7860627, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417726-8670792, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417726-8967760, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417726-9090384, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417726-9288897, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417726-9422767, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417726-9457172, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417726-9548716, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417726-9570752, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417726-9649425, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417726-9714566, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417726-9774671, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417726-9792670, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417726-9826565, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417726-9827430, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417726-9894883, http://linkedlifedata.com/resource/pubmed/commentcorrection/12417726-9922452
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0270-7306
pubmed:author
pubmed:issnType
Print
pubmed:volume
22
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
8226-40
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
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