Linked Life Data

12417657

Source:http://linkedlifedata.com/resource/pubmed/id/12417657

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
21
pubmed:dateCreated
2002-11-5
pubmed:abstractText
Dopamine (DA) facilitates male sexual behavior and modulates aromatase activity in the quail preoptic area (POA). Aromatase neurons in the POA receive dopaminergic inputs, but the anatomical substrate that mediates the behavioral and endocrine effects of DA is poorly understood. Intracellular recordings showed that 100 microm DA hyperpolarizes most neurons in the medial preoptic nucleus (80%) by a direct effect, but depolarizes a few others (10%). DA-induced hyperpolarizations were not blocked by D1 or D2 antagonists (SCH-23390 and sulpiride). Extracellular recordings confirmed that DA inhibits the firing of most cells (52%) but excites a few others (24%). These effects also were not affected by DA antagonists (SCH-23390 and sulpiride) but were blocked by alpha2-(yohimbine) and alpha1-(prazosin) noradrenergic receptor antagonists, respectively. Two dopamine-beta-hydroxylase (DBH) inhibitors (cysteine and fusaric acid) did not block the DA-induced effects, indicating that DA is not converted into norepinephrine (NE) to produce its effects. The pK(B) of yohimbine for the receptor involved in the DA- and NE-induced inhibitions was similar, indicating that the two monoamines interact with the same receptor. Together, these results demonstrate that the effects of DA in the POA are mediated mostly by the activation of alpha2 (inhibition) and alpha1 (excitation) adrenoreceptors. This may explain why DA affects the expression of male sexual behavior through its action in the POA, which contains high densities of alpha2-noradrenergic but limited amounts of DA receptors. This study thus clearly demonstrates the existence of a cross talk within CNS catecholaminergic systems between a neurotransmitter and heterologous receptors.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1529-2401
pubmed:author
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
22
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
9320-30
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:12417657-Action Potentials, pubmed-meshheading:12417657-Adrenergic Antagonists, pubmed-meshheading:12417657-Animals, pubmed-meshheading:12417657-Binding, Competitive, pubmed-meshheading:12417657-Coturnix, pubmed-meshheading:12417657-Dopamine, pubmed-meshheading:12417657-Dopamine Agonists, pubmed-meshheading:12417657-Dopamine Antagonists, pubmed-meshheading:12417657-Dopamine beta-Hydroxylase, pubmed-meshheading:12417657-GABA Antagonists, pubmed-meshheading:12417657-Male, pubmed-meshheading:12417657-Membrane Potentials, pubmed-meshheading:12417657-Microelectrodes, pubmed-meshheading:12417657-Neurons, pubmed-meshheading:12417657-Norepinephrine, pubmed-meshheading:12417657-Preoptic Area, pubmed-meshheading:12417657-Receptors, Adrenergic, pubmed-meshheading:12417657-Synaptic Transmission, pubmed-meshheading:12417657-Tetrodotoxin, pubmed-meshheading:12417657-Yohimbine
pubmed:year
2002
pubmed:articleTitle
Dopamine activates noradrenergic receptors in the preoptic area.
pubmed:affiliation
Center for Cellular and Molecular Neurobiology, Research Group in Behavioral Neuroendocrinology, University of Liège, B-4020 Liège, Belgium. Charlotte.Cornil@ulg.ac.be
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't