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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
19
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pubmed:dateCreated |
2002-11-5
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pubmed:abstractText |
Like endothelial and smooth muscle cells, vascular adventitial fibroblasts contain a substantial NAD(P)H oxidase superoxide anion (O2-)-generating system activated by angiotensin II (Ang II). Based on the ability of nitric oxide (NO*) to diffuse rapidly through tissue and the fast reaction rate of NO* and O2-, we postulated that the interaction between NO. and adventitial NAD(P)H oxidase-derived O2- contributes to impairment of endothelium-dependent relaxation (EDR).
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin II,
http://linkedlifedata.com/resource/pubmed/chemical/CYBB protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Hydrogen Peroxide,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/NADH, NADPH Oxidoreductases,
http://linkedlifedata.com/resource/pubmed/chemical/NADPH Oxidase,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Oxidants,
http://linkedlifedata.com/resource/pubmed/chemical/Oxygen,
http://linkedlifedata.com/resource/pubmed/chemical/Oxyhemoglobins,
http://linkedlifedata.com/resource/pubmed/chemical/Superoxide Dismutase,
http://linkedlifedata.com/resource/pubmed/chemical/Superoxides,
http://linkedlifedata.com/resource/pubmed/chemical/Vasoconstrictor Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Vasodilator Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Xanthine,
http://linkedlifedata.com/resource/pubmed/chemical/Xanthine Oxidase
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1524-4539
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
5
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pubmed:volume |
106
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2497-502
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:12417549-Angiotensin II,
pubmed-meshheading:12417549-Animals,
pubmed-meshheading:12417549-Aorta, Abdominal,
pubmed-meshheading:12417549-Dose-Response Relationship, Drug,
pubmed-meshheading:12417549-Endothelium, Vascular,
pubmed-meshheading:12417549-Hydrogen Peroxide,
pubmed-meshheading:12417549-Membrane Glycoproteins,
pubmed-meshheading:12417549-Mice,
pubmed-meshheading:12417549-Mice, Inbred C57BL,
pubmed-meshheading:12417549-Mice, Knockout,
pubmed-meshheading:12417549-NADH, NADPH Oxidoreductases,
pubmed-meshheading:12417549-NADPH Oxidase,
pubmed-meshheading:12417549-Nitric Oxide,
pubmed-meshheading:12417549-Oxidants,
pubmed-meshheading:12417549-Oxygen,
pubmed-meshheading:12417549-Oxyhemoglobins,
pubmed-meshheading:12417549-Perfusion,
pubmed-meshheading:12417549-Superoxide Dismutase,
pubmed-meshheading:12417549-Superoxides,
pubmed-meshheading:12417549-Vasoconstrictor Agents,
pubmed-meshheading:12417549-Vasodilation,
pubmed-meshheading:12417549-Vasodilator Agents,
pubmed-meshheading:12417549-Xanthine,
pubmed-meshheading:12417549-Xanthine Oxidase
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pubmed:year |
2002
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pubmed:articleTitle |
Perivascular superoxide anion contributes to impairment of endothelium-dependent relaxation: role of gp91(phox).
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pubmed:affiliation |
Hypertension & Vascular Research Division, Henry Ford Hospital, Detroit, Mich 48202-2689, USA.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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