Linked Life Data

12416448

Source:http://linkedlifedata.com/resource/pubmed/id/12416448

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2002-11-5
pubmed:abstractText
The dramatic improvement seen in the latest years in the prognosis of HIV infection has been threatened by long-term toxicities of antiretroviral drugs. Nucleoside analogs remain the cornerstone of antiretroviral therapy, but these compounds seem to produce mitochondrial damage leading to a broad range of side effects, which depend of the organ/tissue affected. Among those toxicities are of particular concern lipoatrophy and hyperlactatemia syndromes. This review will focus on the pathogenesis of mitochondrion damage caused by nucleoside analogs and its clinical consequences, particularly in respect to body-shape changes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1139-6121
pubmed:author
pubmed:issnType
Print
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
140-7
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:articleTitle
Update on mitochondrial toxicity of antiretrovirals and its link to lipodystrophy.
pubmed:affiliation
Rainbow Babies and Children's Hospital, Case Western Reserve University Center for AIDS Research, Cleveland, Ohio, USA. mccomsey.grace@clevelandactu.org
pubmed:publicationType
Journal Article, Review