Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2002-11-4
pubmed:abstractText
Insular and SII cortices have been consistently shown by PET, fMRI, EPs, and MEG techniques to be activated bilaterally by a nociceptive stimulation. The aim of the present study was to refer to, and to compare within a common stereotactic space, the nociceptive responses obtained in humans by (i) PET, (ii) fMRI, (iii) dipole modeling of scalp LEPs, and (iv) intracerebral recordings of LEPs. PET, fMRI, and scalp LEPs were obtained from normal subjects during thermal pain. Operculoinsular LEPs were obtained from 13 patients using deep brain electrodes implanted for presurgical evaluation of drug-resistant epilepsy. Whatever the technique, we obtained responses which were located bilaterally in the insular and SII cortices. In electrophysiological responses (LEPs) the SII insular contribution peaked between 150 and 250 ms poststimulus and corresponded to the earliest portions of the whole cerebral response. Group analysis of PET and fMRI data showed highly consistent responses contralateral to stimulation. On single-subject analysis, LEPs and fMRI activations were concentrated in relatively restricted volumes even though spatial sampling was quite different for both techniques. Despite our multimodal approach, however, it was not possible to separate insular from SII activities. Individual variations in the anatomy and function of SII and insular cortices may explain this limitation. This multimodal study provides, however, cross-validated spatial and temporal information on the pain-related processes occurring in the operculoinsular region, which thus appears as a major site for the early cortical pain encoding in the human brain.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1053-8119
pubmed:author
pubmed:issnType
Print
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1336-46
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:12414273-Adult, pubmed-meshheading:12414273-Brain Mapping, pubmed-meshheading:12414273-Cerebral Cortex, pubmed-meshheading:12414273-Dominance, Cerebral, pubmed-meshheading:12414273-Electrodes, Implanted, pubmed-meshheading:12414273-Electroencephalography, pubmed-meshheading:12414273-Epilepsy, Temporal Lobe, pubmed-meshheading:12414273-Female, pubmed-meshheading:12414273-Frontal Lobe, pubmed-meshheading:12414273-Humans, pubmed-meshheading:12414273-Image Processing, Computer-Assisted, pubmed-meshheading:12414273-Magnetic Resonance Imaging, pubmed-meshheading:12414273-Male, pubmed-meshheading:12414273-Middle Aged, pubmed-meshheading:12414273-Nociceptors, pubmed-meshheading:12414273-Oxygen, pubmed-meshheading:12414273-Pain, pubmed-meshheading:12414273-Pain Threshold, pubmed-meshheading:12414273-Synaptic Transmission, pubmed-meshheading:12414273-Tomography, Emission-Computed
pubmed:year
2002
pubmed:articleTitle
Role of operculoinsular cortices in human pain processing: converging evidence from PET, fMRI, dipole modeling, and intracerebral recordings of evoked potentials.
pubmed:affiliation
Clinical Neurophysiology and Epileptology Department, Lyon, France. Roland.Peyron@univ-st-etienne.fr
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't