Linked Life Data

12414122

Source:http://linkedlifedata.com/resource/pubmed/id/12414122

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2002-11-4
pubmed:abstractText
Leukemia inhibitory factor (LIF) is a pluripotent cytokine which affects the survival and differentiation of various types of cells both in the hematopoietic and nervous systems. In this study, the time course and localization of LIF mRNA expression following kainic acid-induced seizures were examined by northern blot analyses and in situ hybridization. Northern blot analyses demonstrated that intraperitoneal injection of kainic acid at a convulsive dose induced LIF mRNA expression intensely in the hippocampus and moderately to weakly in the cerebral cortex, thalamus and hypothalamus. The expression peaked at 8-24 h after the injection in the hippocampus and cerebral cortex and at 8 h in the thalamus and hypothalamus. In situ hybridization revealed different time courses of LIF mRNA expression depending on the area of the hippocampus; that is, the expression peaked at 10 h in the granule cell layer of the dentate gyrus, then at 12 h in the polymorph and molecular layers of the dentate gyrus, and finally at 12-24 h in the strata oriens and radiatum of the CA1 and CA3 subfields. It is worth noting that the expression of LIF mRNA was intense in the dentate gyrus, the region where neurogenesis and aberrant network reorganization have been shown to be induced by seizures. The upregulation of LIF mRNA expression in the dentate granule cell layer followed by that in the dentate polymorph and molecular layers may be involved in activity-dependent neurogenesis in the granule cell layer and ectopic migration of granule cells to the polymorph and molecular layers in the dentate gyrus.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0169-328X
pubmed:author
pubmed:issnType
Print
pubmed:day
30
pubmed:volume
107
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
39-46
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:12414122-Animals, pubmed-meshheading:12414122-Cell Differentiation, pubmed-meshheading:12414122-Cell Division, pubmed-meshheading:12414122-Cell Movement, pubmed-meshheading:12414122-Dentate Gyrus, pubmed-meshheading:12414122-Excitatory Amino Acid Agonists, pubmed-meshheading:12414122-Gene Expression Regulation, pubmed-meshheading:12414122-Growth Inhibitors, pubmed-meshheading:12414122-Hippocampus, pubmed-meshheading:12414122-Interleukin-6, pubmed-meshheading:12414122-Kainic Acid, pubmed-meshheading:12414122-Leukemia Inhibitory Factor, pubmed-meshheading:12414122-Lymphokines, pubmed-meshheading:12414122-Male, pubmed-meshheading:12414122-Neurons, pubmed-meshheading:12414122-RNA, Messenger, pubmed-meshheading:12414122-Rats, pubmed-meshheading:12414122-Rats, Sprague-Dawley, pubmed-meshheading:12414122-Seizures, pubmed-meshheading:12414122-Time Factors, pubmed-meshheading:12414122-Up-Regulation
pubmed:year
2002
pubmed:articleTitle
Kainic acid induces leukemia inhibitory factor mRNA expression in the rat brain: differences in the time course of mRNA expression between the dentate gyrus and hippocampal CA1/CA3 subfields.
pubmed:affiliation
Department of Molecular Pharmacology, Faculty of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan.
pubmed:publicationType
Journal Article, Comparative Study