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rdf:type |
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lifeskim:mentions |
umls-concept:C0007765,
umls-concept:C0017262,
umls-concept:C0031603,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0185117,
umls-concept:C0682737,
umls-concept:C1424492,
umls-concept:C1424493,
umls-concept:C1564137,
umls-concept:C2911684
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pubmed:issue |
1
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pubmed:dateCreated |
2002-11-4
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pubmed:abstractText |
Expression of inorganic phosphate/vesicular glutamate transporters (BNPI/VGLUT1 and DNPI/VGLUT2) was studied in the cerebellum and precerebellar nuclei of rats using immunohistochemistry and in situ hybridization. DNPI/VGLUT2-stained mossy fibers were principally seen in the vermis (lobules I and VIII-X) and flocculus, whereas BNPI/VGLUT1-stained mossy fibers were localized throughout the cortex. Some vermal and floccular mossy fibers were stained for both transporters. High levels of DNPI/VGLUT2 mRNA hybridization signals were demonstrated in many neurons throughout the vestibular nuclear complex as well as the lateral reticular, external cuneate, inferior olivary and deep cerebellar nuclei. Significant BNPI/VGLUT1 mRNA signals were demonstrated in the lateral reticular nucleus and vestibular nuclear complex but not in the inferior olivary nucleus, indicating that climbing fibers have DNPI/VGLUT2 only. These results show that DNPI/VGLUT2 is expressed preferentially to vestibulo-, reticulo- and cuneocerebellar neurons, some of which also possess BNPI/VGLUT1, suggesting some differential and co-operative functions between DNPI/VGLUT2 and BNPI/VGLUT1 in the cerebellum.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Glutamic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Transport Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphates,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Slc17a6 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Slc17a7 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Vesicular Glutamate Transport...,
http://linkedlifedata.com/resource/pubmed/chemical/Vesicular Glutamate Transport...,
http://linkedlifedata.com/resource/pubmed/chemical/Vesicular Transport Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0169-328X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
30
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pubmed:volume |
107
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
23-31
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:12414120-Animals,
pubmed-meshheading:12414120-Brain Stem,
pubmed-meshheading:12414120-Carrier Proteins,
pubmed-meshheading:12414120-Cerebellum,
pubmed-meshheading:12414120-Gene Expression,
pubmed-meshheading:12414120-Glutamic Acid,
pubmed-meshheading:12414120-Immunohistochemistry,
pubmed-meshheading:12414120-Male,
pubmed-meshheading:12414120-Membrane Transport Proteins,
pubmed-meshheading:12414120-Nerve Fibers,
pubmed-meshheading:12414120-Neural Pathways,
pubmed-meshheading:12414120-Olivary Nucleus,
pubmed-meshheading:12414120-Phosphates,
pubmed-meshheading:12414120-RNA, Messenger,
pubmed-meshheading:12414120-Rats,
pubmed-meshheading:12414120-Rats, Sprague-Dawley,
pubmed-meshheading:12414120-Reticular Formation,
pubmed-meshheading:12414120-Synaptic Transmission,
pubmed-meshheading:12414120-Vesicular Glutamate Transport Protein 1,
pubmed-meshheading:12414120-Vesicular Glutamate Transport Protein 2,
pubmed-meshheading:12414120-Vesicular Transport Proteins,
pubmed-meshheading:12414120-Vestibular Nuclei
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pubmed:year |
2002
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pubmed:articleTitle |
Expression of inorganic phosphate/vesicular glutamate transporters (BNPI/VGLUT1 and DNPI/VGLUT2) in the cerebellum and precerebellar nuclei of the rat.
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pubmed:affiliation |
Laboratory of Neuroendocrinology, Institute of Basic Medical Sciences, University of Tsukuba, Tennodai 1-1-1, Tsukuba, Ibaraki 305-8575, Japan. shisano@md.tsukuba.ac.jp
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pubmed:publicationType |
Journal Article
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