Linked Life Data

12413060

Source:http://linkedlifedata.com/resource/pubmed/id/12413060

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2002-11-4
pubmed:abstractText
Cells traffic in both directions between the fetus and the mother during pregnancy. Recent studies indicate that a low level of fetal cells commonly persists in the maternal circulation for years after pregnancy completion. The harboring of DNA or cells from another individual at low levels is called microchimerism. Chronic graft-vs-host disease is a condition of human chimerism that shares similarities to some autoimmune diseases and for which the specific HLA genes of donor and host are known to be of central importance. Considered together with the female predilection to autoimmunity, these observations led to the hypothesis that microchimerism and HLA genes of host and non-host cells are involved in autoimmune disease. The hypothesis also extends to men and females who have not been pregnant because there are other sources of microchimerism. Maternal cells are now know to persist in her progeny and microchimerism can also derive from a twin or from a blood transfusion. Studies of systemic sclerosis, primary biliary cirrhosis, Sjögrens syndrome, polymorpyhic eruption of pregnancy, myositis and thyroid disease have both lent support and raised doubts about the role of microchimerism in autoimmune disease.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0961-2033
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
651-4
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Microchimerism and human autoimmune diseases.
pubmed:affiliation
Program in Human Immunogenetics, Fred Hutchinson Cancer Research Center, and Rheumatology, University of Washington, Seattle 98109-1024, USA. lnelson@fhcrc.org
pubmed:publicationType
Journal Article, Review