Linked Life Data

12412978

Source:http://linkedlifedata.com/resource/pubmed/id/12412978

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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2002-11-4
pubmed:abstractText
Worsening of underlying bronchospasm may be associated with acute exacerbations of chronic obstructive pulmonary disease (COPD). As airway obstruction becomes more severe, the therapeutic option is to add salbutamol, but not salmeterol, as needed to cause rapid relief of bronchospasm. Unfortunately the most effective dosage of beta2-agonists may increase above that recommended during acute exacerbations. In this study, we compared the acute effects of higher than customary doses of salmeterol and salbutamol in 20 patients with acute exacerbation of COPD. A dose-response curve to salmeterol pMDI, 25 microg/puff or salbutamol pMDI, 100 microg/puff, was constructed using 1, 1, and 2 puff' i.e., a total cumulative dose of 100 microg salmeterol or 400 microg salbutamol on 2 consecutive days. After baseline measurements, dose increments were given at 30-min intervals with measurements being made 25 min after each dose. Hear rate (HR) and pulse-oximetry (SpO2) measurements were then taken. Both salmeterol and salbutamol induced a larg and significant (P < 0.05) dose-dependent increase in FEV1 [mean differences from baseline (L) = after 100 microg salmeterol 0.174 (95% CI: 0.112 to 0.237); after 400 microg salbutamol: 0.165 (95% CI: 0.080 to 0.249)], in IC [mean differences from baseline (L) = after 100 microg salmeterol: 0.332 (95% CI: 0.165 to 0.499); after 400 microg salbutamol: 0.281 (95% CI: 0.107 to 0.456)] (Fig. 2), and in FVC mean differences from baseline (L) = after 100 microg salmeterol: 0.224 (95% CI: 0.117 to 0.331); after 400 microg salbutamol: 0.242 (95% CI: 0.090 to 0.395)]. There was no significant difference between the FEV1 values (P=0.418), the ICvalues (P=0.585), and the FVCvalue (P=0.610) after 100 microg salmeterol and 400 microg salbutamol. HR [mean differences from baseline (beats/min) = after 100 microg salmeterol: 3.15 (95% CI: -0.65 to 6.96); after 400 microg salbutamol: 2.30 (95% CI: -0.91 to 5.51)] and SpO2 [mean differences from baseline (%) = after 100 microg salmeterol: -0.20 (95% CI: -1.00 to 0.60); after 400 microg salbutamol: -0.11 (95% CI: -1.00 to 0.79)] did not change significantly from baseline (P > 0.05). These data indicate that salmeterol is effective and safe in the treatment of acute exacerbation of COPD and support its use in this clinical condition.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0954-6111
pubmed:author
pubmed:issnType
Print
pubmed:volume
96
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
790-5
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed-meshheading:12412978-Acute Disease, pubmed-meshheading:12412978-Administration, Inhalation, pubmed-meshheading:12412978-Adrenergic beta-Agonists, pubmed-meshheading:12412978-Aged, pubmed-meshheading:12412978-Albuterol, pubmed-meshheading:12412978-Bronchodilator Agents, pubmed-meshheading:12412978-Dose-Response Relationship, Drug, pubmed-meshheading:12412978-Drug Administration Schedule, pubmed-meshheading:12412978-Drug Therapy, Combination, pubmed-meshheading:12412978-Female, pubmed-meshheading:12412978-Forced Expiratory Volume, pubmed-meshheading:12412978-Heart Rate, pubmed-meshheading:12412978-Humans, pubmed-meshheading:12412978-Male, pubmed-meshheading:12412978-Middle Aged, pubmed-meshheading:12412978-Oxygen, pubmed-meshheading:12412978-Partial Pressure, pubmed-meshheading:12412978-Pulmonary Disease, Chronic Obstructive
pubmed:year
2002
pubmed:articleTitle
Acute effects of higher than customary doses of salmeterol and salbutamol in patients with acute exacerbation of COPD.
pubmed:affiliation
A Cardarelli Hospital, Department of Respiratory Medicine, Naples, Italy. mcazzola@qubisoft.it
pubmed:publicationType
Journal Article, Clinical Trial, Randomized Controlled Trial, Multicenter Study