Source:http://linkedlifedata.com/resource/pubmed/id/12412671
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2002-11-4
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| pubmed:abstractText |
The authors investigated changes in asthma prevalence and perception of bronchoconstriction over 6 yrs in adults of Newcastle-upon-Tyne. Postal questionnaires were sent to 6,000 subjects aged 20-44 yrs in 1992-1993 and 1998-1999. Random samples of 600 responders had assessments of atopy, airway responsiveness, and their ability to perceive methacholine-induced bronchoconstriction. The prevalences of asthmatic symptoms, physician-diagnosis, and medication use increased by an average of 4.4%, particularly in subjects aged <30 yrs (8.7 versus 2.7). Atopy prevalence increased from 25% to 31% but atopics and nonatopics had similar mean changes in questionnaire data (5.2 versus 3.4). The probability of a positive methacholine test decreased as did the mean methacholine dose/response slope (0.00527 to 0.00379), indicating lower levels of airway responsiveness. This can be largely explained by an increase in use of inhaled corticosteroids (5.0-9.3%). The proportion of subjects perceiving bronchoconstriction during methacholine tests increased from 63 to 77%. The authors conclude that current changes in asthma epidemiology in adults may result from increased awareness of symptoms (and/or an increased willingness to report them), and from an increased willingness of physicians to make the diagnosis and prescribe treatment, not from increased disease prevalence.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
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| pubmed:issn |
0903-1936
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
20
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
826-33
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:12412671-Adolescent,
pubmed-meshheading:12412671-Adult,
pubmed-meshheading:12412671-Age Distribution,
pubmed-meshheading:12412671-Aged,
pubmed-meshheading:12412671-Asthma,
pubmed-meshheading:12412671-Bronchial Provocation Tests,
pubmed-meshheading:12412671-Chi-Square Distribution,
pubmed-meshheading:12412671-Child,
pubmed-meshheading:12412671-Female,
pubmed-meshheading:12412671-Great Britain,
pubmed-meshheading:12412671-Humans,
pubmed-meshheading:12412671-Linear Models,
pubmed-meshheading:12412671-Logistic Models,
pubmed-meshheading:12412671-Male,
pubmed-meshheading:12412671-Methacholine Chloride,
pubmed-meshheading:12412671-Middle Aged,
pubmed-meshheading:12412671-Population Surveillance,
pubmed-meshheading:12412671-Prevalence,
pubmed-meshheading:12412671-Probability,
pubmed-meshheading:12412671-Questionnaires,
pubmed-meshheading:12412671-Respiratory Function Tests,
pubmed-meshheading:12412671-Risk Factors,
pubmed-meshheading:12412671-Severity of Illness Index,
pubmed-meshheading:12412671-Sex Distribution
|
| pubmed:year |
2002
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| pubmed:articleTitle |
Apparent but not real increase in asthma prevalence during the 1990s.
|
| pubmed:affiliation |
Dept of Respiratory Medicine, Royal Victoria Infirmary, University of Newcastle-upon-Tyne, UK.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|