Linked Life Data

1241266

Source:http://linkedlifedata.com/resource/pubmed/id/1241266

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1976-5-20
pubmed:abstractText
Pharmacological properties of alpha-(AFG), beta-(FG) and gamma-(GFM) phenyl-substituted derivatives of GABA and their respective lactams (FP, FL, FM) were studied in rats and mice. All studied compounds diminished spontaneous and pharmacologically potentiated motility, lowered body temperature of mice, and weakened conditioned reflexes in rats. Some of the compounds (AFG, FG, FP) diminished activity of rats in the open-field test and symptoms of amphetamine- (AFG, FG, FP, FL, FM) and apomorphine-induced stereotypy (FL, FG). FG evoked catalepsy and potentiated chlorpromazine catalepsy in mice. The compounds potentiated action of narcotic and subthreshold doses of barbiturates and ethanol, had analgesic properties, and potentiated analgesic action of morphine. The most active and least toxic compound was beta-phenyl-gamma-aminobutyric acid (FG).
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0004-069X
pubmed:author
pubmed:issnType
Print
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
733-46
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1975
pubmed:articleTitle
Pharmacological properties of gamma-animobutyric acid and it derivatives. IV. Aryl gaba derivatives and their respective lactams.
pubmed:publicationType
Journal Article