Linked Life Data

12409294

Source:http://linkedlifedata.com/resource/pubmed/id/12409294

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2003-1-6
pubmed:abstractText
Light is a prominent stimulus that synchronizes endogenous circadian rhythmicity to environmental light/dark cycles. Nocturnal light elevates mRNA of the Period1 (Per1) gene and induces long term state changes, expressed as phase shifts of circadian rhythms. The cellular mechanism for Per1 elevation and light-induced phase advance in the suprachiasmatic nucleus (SCN), a process initiated primarily by glutamatergic neurotransmission from the retinohypothalamic tract, was examined. Glutamate (GLU)-induced phase advances in the rat SCN were blocked by antisense oligodeoxynucleotide (ODN) against Per1 and Ca(2+)/cAMP response element (CRE)-decoy ODN. CRE-decoy ODN also blocked light-induced phase advances in vivo. Furthermore, the CRE-decoy blocked GLU-induced accumulation of Per1 mRNA. Thus, Ca(2+)/cAMP response element-binding protein (CREB) and Per1 are integral components of the pathway transducing light-stimulated GLU neurotransmission into phase advance of the circadian clock.
pubmed:grant
http://linkedlifedata.com/resource/pubmed/grant/HL67007, http://linkedlifedata.com/resource/pubmed/grant/MH12351, http://linkedlifedata.com/resource/pubmed/grant/NS10170, http://linkedlifedata.com/resource/pubmed/grant/NS11158, http://linkedlifedata.com/resource/pubmed/grant/NS22155, http://linkedlifedata.com/resource/pubmed/grant/R01 HL067007-05A1, http://linkedlifedata.com/resource/pubmed/grant/R01 HL067007-06, http://linkedlifedata.com/resource/pubmed/grant/R01 HL067007-07, http://linkedlifedata.com/resource/pubmed/grant/R01 HL067007-08, http://linkedlifedata.com/resource/pubmed/grant/R01 NS022155-14, http://linkedlifedata.com/resource/pubmed/grant/R01 NS022155-15A1, http://linkedlifedata.com/resource/pubmed/grant/R01 NS022155-16, http://linkedlifedata.com/resource/pubmed/grant/R01 NS022155-17, http://linkedlifedata.com/resource/pubmed/grant/R01 NS022155-18
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0021-9258
pubmed:author
pubmed:issnType
Print
pubmed:day
10
pubmed:volume
278
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
718-23
pubmed:dateRevised
2010-8-10
pubmed:meshHeading
pubmed-meshheading:12409294-Animals, pubmed-meshheading:12409294-Calcium, pubmed-meshheading:12409294-Cell Cycle Proteins, pubmed-meshheading:12409294-Circadian Rhythm, pubmed-meshheading:12409294-Cyclic AMP Response Element-Binding Protein, pubmed-meshheading:12409294-Cyclic AMP-Dependent Protein Kinases, pubmed-meshheading:12409294-Gene Expression Regulation, pubmed-meshheading:12409294-Glutamic Acid, pubmed-meshheading:12409294-Light, pubmed-meshheading:12409294-Male, pubmed-meshheading:12409294-Mice, pubmed-meshheading:12409294-Nitric Oxide, pubmed-meshheading:12409294-Nuclear Proteins, pubmed-meshheading:12409294-Period Circadian Proteins, pubmed-meshheading:12409294-Rats, pubmed-meshheading:12409294-Rats, Long-Evans, pubmed-meshheading:12409294-Response Elements, pubmed-meshheading:12409294-Suprachiasmatic Nucleus
pubmed:year
2003
pubmed:articleTitle
Ca2+/cAMP response element-binding protein (CREB)-dependent activation of Per1 is required for light-induced signaling in the suprachiasmatic nucleus circadian clock.
pubmed:affiliation
Department of Cell and Structural Biology, University of Illinois at Urbana-Champaign, B107 CLSL, 61801, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.