Linked Life Data

12409216

Source:http://linkedlifedata.com/resource/pubmed/id/12409216

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-3
pubmed:dateCreated
2002-10-31
pubmed:abstractText
The bed nuclei of the stria terminalis (BST) and the central nucleus of the amygdala are highly heterogeneous structures, which form one functional unit, the so-called extended amygdala. Several studies described increased c-fos expression following acute stress in this brain area, confirming its central role in the modulation/regulation of stress responses. The oval nucleus of the BST and the central amygdala exhibit a dense network of pituitary adenylate cyclase-activating polypeptide (PACAP)-immunoreactive (ir) fiber terminals. In addition, several dopamine- and cyclic AMP-regulated phosphoprotein (DARPP-32)-immunoreactive neurons were also observed here. Because the extended amygdala plays an important role in the central autonomic regulation during stress and the distribution of PACAP-ir and that of DARPP-32-ir nervous structures overlap, the aims of this study were to investigate the possible activation of DARPP-32-ir neurons following acute systemic stress and to demonstrate synaptic interactions between DARPP-32-ir neurons and fiber terminals immunopositive for PACAP.In summary, this study provided morphological evidence that acute stress resulted in the activation of DARPP-32 neurons, which were innervated by PACAP-ir neuronal structures in the extended amygdala. Furthermore, interaction between neuropeptides/neurotransmitters and phosphoproteins was also demonstrated.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0167-0115
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
109
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
63-70
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:12409216-Amygdala, pubmed-meshheading:12409216-Animals, pubmed-meshheading:12409216-Dopamine, pubmed-meshheading:12409216-Dopamine and cAMP-Regulated Phosphoprotein 32, pubmed-meshheading:12409216-Immunohistochemistry, pubmed-meshheading:12409216-Male, pubmed-meshheading:12409216-Microscopy, Electron, pubmed-meshheading:12409216-Nerve Tissue Proteins, pubmed-meshheading:12409216-Neurons, pubmed-meshheading:12409216-Neuropeptides, pubmed-meshheading:12409216-Neurotransmitter Agents, pubmed-meshheading:12409216-Oncogene Proteins v-fos, pubmed-meshheading:12409216-Phosphoproteins, pubmed-meshheading:12409216-Pituitary Adenylate Cyclase-Activating Polypeptide, pubmed-meshheading:12409216-Rats, pubmed-meshheading:12409216-Rats, Wistar, pubmed-meshheading:12409216-Stress, Physiological
pubmed:year
2002
pubmed:articleTitle
Dopamine- and cyclic AMP-regulated phosphoprotein-immunoreactive neurons activated by acute stress are innervated by fiber terminals immunopositive for pituitary adenylate cyclase-activating polypeptide in the extended amygdala in the rat.
pubmed:affiliation
Medical Faculty, Department of Human Anatomy, University of Pécs, Hungary. tkozicz2000@yahoo.com
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't