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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2002-10-31
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pubmed:abstractText |
We investigated expression of costimulatory molecules BB-1, B7-1 (CD80), B7-2 (CD86), and their counter-receptors CD28 and CTLA-4 (CD152) in muscle biopsy specimens of patients with scleroderma-polymyositis overlap syndrome (SSc-PM), primary polymyositis (PM), and other related diseases to examine whether the muscle fibers in patients with SSc-PM behave as antigen-presenting cells (APCs). The major histocompatibility (MHC) class II-positive muscle fibers of SSc-PM patients reacted with monoclonal antibodies (mAb) against BB-1 but not against B7-1 or B7-2. The CD4+ T cells expressed the counter-receptors CD28 and CTLA-4, and bound with the BB-1-positive muscle fibers in cell-to-cell contact. Our findings show that muscle fibers in patients with SSc-PM function as "professional" APCs in a way distinct from muscle fibers in patients with primary PM.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD28,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD4,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD8,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD80,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/CTLA-4 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/CTLA4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens Class II,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoconjugates,
http://linkedlifedata.com/resource/pubmed/chemical/Map protein, Staphylococcus aureus,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/abatacept,
http://linkedlifedata.com/resource/pubmed/chemical/invariant chain
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0022-510X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
205
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
65-70
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:12409186-Adult,
pubmed-meshheading:12409186-Aged,
pubmed-meshheading:12409186-Antigens, CD,
pubmed-meshheading:12409186-Antigens, CD28,
pubmed-meshheading:12409186-Antigens, CD4,
pubmed-meshheading:12409186-Antigens, CD8,
pubmed-meshheading:12409186-Antigens, CD80,
pubmed-meshheading:12409186-Antigens, Differentiation,
pubmed-meshheading:12409186-Antigens, Differentiation, B-Lymphocyte,
pubmed-meshheading:12409186-Bacterial Proteins,
pubmed-meshheading:12409186-Biopsy,
pubmed-meshheading:12409186-CTLA-4 Antigen,
pubmed-meshheading:12409186-Female,
pubmed-meshheading:12409186-Histocompatibility Antigens Class II,
pubmed-meshheading:12409186-Humans,
pubmed-meshheading:12409186-Immunoconjugates,
pubmed-meshheading:12409186-Immunohistochemistry,
pubmed-meshheading:12409186-Middle Aged,
pubmed-meshheading:12409186-Polymyositis,
pubmed-meshheading:12409186-RNA, Messenger,
pubmed-meshheading:12409186-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:12409186-Scleroderma, Systemic
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pubmed:year |
2002
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pubmed:articleTitle |
Expression of the costimulatory molecule BB-1 and its receptors in patients with scleroderma-polymyositis overlap syndrome.
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pubmed:affiliation |
Department of Neurology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8521, Japan. kemurata@naramed-u.ac.jp
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pubmed:publicationType |
Journal Article
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