Linked Life Data

12408905

Source:http://linkedlifedata.com/resource/pubmed/id/12408905

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2002-10-31
pubmed:abstractText
A simple isocratic reversed-phase high performance liquid chromatograghic method for the separation of pseudoephedrine and its related compounds in pharmaceutical formulations is described. The separation is achieved in less than 35 min on a C-18 column (4.6 mm I.D. x 25 cm length, 5-micrometer particle size) using a mobile phase consisting of a mixture of ammonium acetate and methanol. The results described in this report demonstrate that the method is sensitive and selective. Structural elucidation of two new pseudoephedrine degradation products is described. On the basis of structural analysis by liquid chromatography-mass spectrometry (LC-MS) and liquid chromatography-nuclear magnetic resonance spectroscopy (LC-NMR), the two newly elucidated degradation products were identified to be 2-(carboxyamino)propiophenone (molecular ion of m/z=194) and 2-formyl-2-(methylamino)-acetophenone (molecular ion of m/z=178).
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0731-7085
pubmed:author
pubmed:issnType
Print
pubmed:day
7
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1143-55
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Quantitative and structural determination of pseudoephedrine sulfate and its related compounds in pharmaceutical preparations using high-performance liquid chromatography.
pubmed:affiliation
Analytical Development, Schering Plough Research Institute, 2011 Galloping Hill Road, 07033, Kenilworth, NJ, USA. nian.wu@spcorp.com
pubmed:publicationType
Journal Article