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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2002-10-31
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pubmed:abstractText |
In a genetic screen for genes that control synapse development, we have identified spinster (spin), which encodes a multipass transmembrane protein. spin mutant synapses reveal a 200% increase in bouton number and a deficit in presynaptic release. We demonstrate that spin is expressed in both nerve and muscle and is required both pre- and postsynaptically for normal synaptic growth. We have localized Spin to a late endosomal compartment and present evidence for altered endosomal/lysosomal function in spin. We also present evidence that synaptic overgrowth in spin is caused by enhanced/misregulated TGF-beta signaling. TGF-beta receptor mutants show dose-dependent suppression of synaptic overgrowth in spin. Furthermore, mutations in Dad, an inhibitory Smad, cause synapse overgrowth. We present a model for synaptic growth control with implications for the etiology of lysosomal storage and neurodegenerative disease.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0896-6273
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
24
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pubmed:volume |
36
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
403-16
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12408844-Animals,
pubmed-meshheading:12408844-Cell Compartmentation,
pubmed-meshheading:12408844-Cell Differentiation,
pubmed-meshheading:12408844-Drosophila Proteins,
pubmed-meshheading:12408844-Drosophila melanogaster,
pubmed-meshheading:12408844-Endosomes,
pubmed-meshheading:12408844-Female,
pubmed-meshheading:12408844-Gene Expression Regulation, Developmental,
pubmed-meshheading:12408844-HeLa Cells,
pubmed-meshheading:12408844-Humans,
pubmed-meshheading:12408844-Hypertrophy,
pubmed-meshheading:12408844-Lysosomes,
pubmed-meshheading:12408844-Male,
pubmed-meshheading:12408844-Membrane Proteins,
pubmed-meshheading:12408844-Motor Neurons,
pubmed-meshheading:12408844-Muscle, Skeletal,
pubmed-meshheading:12408844-Mutation,
pubmed-meshheading:12408844-Nervous System,
pubmed-meshheading:12408844-Neuromuscular Junction,
pubmed-meshheading:12408844-Presynaptic Terminals,
pubmed-meshheading:12408844-Synaptic Transmission,
pubmed-meshheading:12408844-Transforming Growth Factor beta
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pubmed:year |
2002
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pubmed:articleTitle |
Unrestricted synaptic growth in spinster-a late endosomal protein implicated in TGF-beta-mediated synaptic growth regulation.
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pubmed:affiliation |
Department of Biochemistry, 513 Parnassus Avenue, HSE 901, University of California, San Francisco, San Francisco, CA 94143, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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