Source:http://linkedlifedata.com/resource/pubmed/id/12408810
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2002-10-31
|
| pubmed:abstractText |
Recent data indicate that cystic fibrosis (CF) airway mucus is anaerobic. This suggests that Pseudomonas aeruginosa infection in CF reflects biofilm formation and persistence in an anaerobic environment. P. aeruginosa formed robust anaerobic biofilms, the viability of which requires rhl quorum sensing and nitric oxide (NO) reductase to modulate or prevent accumulation of toxic NO, a byproduct of anaerobic respiration. Proteomic analyses identified an outer membrane protein, OprF, that was upregulated approximately 40-fold under anaerobic versus aerobic conditions. Further, OprF exists in CF mucus, and CF patients raise antisera to OprF. An oprF mutant formed poor anaerobic biofilms, due, in part, to defects in anaerobic respiration. Thus, future investigations of CF pathogenesis and therapy should include a better understanding of anaerobic metabolism and biofilm development by P. aeruginosa.
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| pubmed:grant | |
| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
1534-5807
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| pubmed:author |
pubmed-author:AllenHolly LHL,
pubmed-author:BoucherRichard CRC,
pubmed-author:DeKievitTeresa RTR,
pubmed-author:GardnerPaul RPR,
pubmed-author:HancockRobert E WRE,
pubmed-author:HassettDaniel JDJ,
pubmed-author:HenniganRobert FRF,
pubmed-author:HilliardGeorge MGM,
pubmed-author:IglewskiBarbara HBH,
pubmed-author:KamaniMoneesha CMC,
pubmed-author:MasonRonald PRP,
pubmed-author:McDermottTimothy RTR,
pubmed-author:NoahTerry LTL,
pubmed-author:OchsnerUrs AUA,
pubmed-author:ParsekMatthew RMR,
pubmed-author:ParvatiyarKislayK,
pubmed-author:RoweJohn JJJ,
pubmed-author:SchwabUteU,
pubmed-author:WozniakDaniel JDJ,
pubmed-author:YoonSang SunSS
|
| pubmed:issnType |
Print
|
| pubmed:volume |
3
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
593-603
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading | |
| pubmed:year |
2002
|
| pubmed:articleTitle |
Pseudomonas aeruginosa anaerobic respiration in biofilms: relationships to cystic fibrosis pathogenesis.
|
| pubmed:affiliation |
Department of Molecular Genetics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|