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rdf:type |
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lifeskim:mentions |
umls-concept:C0007595,
umls-concept:C0018270,
umls-concept:C0019704,
umls-concept:C0030657,
umls-concept:C0041215,
umls-concept:C0081162,
umls-concept:C0220781,
umls-concept:C0220825,
umls-concept:C0243071,
umls-concept:C0243077,
umls-concept:C0431085,
umls-concept:C0597032,
umls-concept:C1883254
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pubmed:issue |
23
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pubmed:dateCreated |
2002-10-31
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pubmed:abstractText |
A well-defined series of 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine analogues was designed and synthesized in order to further ascertain the optimal structural requirements for S-adenosylmethionine decarboxylase inhibition and potentially to augment and perhaps separate their antiproliferative and antitrypanosomal activities. Most structural modifications had a deleterious affect on both the antitrypanosomal and antineoplastic activity of 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine. However, di-O-acetylation of the parent compound produced a potential prodrug that caused markedly pronounced inhibition of trypanosomal and neoplastic cell growth and viability. Moreover, the acetylated derivative of 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine did inhibit HIV-1 growth and infectivity, whereas the parent compound did not.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0022-2623
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pubmed:author |
pubmed-author:BacchiCyrus JCJ,
pubmed-author:BernackiRalphR,
pubmed-author:IyerNathanN,
pubmed-author:KramerDebora LDL,
pubmed-author:KuceraLouisL,
pubmed-author:MarascoCanio JCJJr,
pubmed-author:MillerJohnJ,
pubmed-author:PeraPaulaP,
pubmed-author:PorterCarl WCW,
pubmed-author:RattendiDonnaD,
pubmed-author:SufrinJanice RJR
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pubmed:issnType |
Print
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pubmed:day |
7
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pubmed:volume |
45
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5112-22
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12408722-Adenosylmethionine Decarboxylase,
pubmed-meshheading:12408722-Animals,
pubmed-meshheading:12408722-Anti-HIV Agents,
pubmed-meshheading:12408722-Antineoplastic Agents,
pubmed-meshheading:12408722-Cell Line,
pubmed-meshheading:12408722-Deoxyadenosines,
pubmed-meshheading:12408722-Drug Screening Assays, Antitumor,
pubmed-meshheading:12408722-HIV-1,
pubmed-meshheading:12408722-Humans,
pubmed-meshheading:12408722-Male,
pubmed-meshheading:12408722-Mice,
pubmed-meshheading:12408722-Structure-Activity Relationship,
pubmed-meshheading:12408722-Trypanocidal Agents,
pubmed-meshheading:12408722-Trypanosoma brucei brucei,
pubmed-meshheading:12408722-Trypanosoma brucei rhodesiense,
pubmed-meshheading:12408722-Trypanosomiasis,
pubmed-meshheading:12408722-Tumor Cells, Cultured
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pubmed:year |
2002
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pubmed:articleTitle |
Synthesis and evaluation of analogues of 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine as inhibitors of tumor cell growth, trypanosomal growth, and HIV-1 infectivity.
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pubmed:affiliation |
Department of Pharmacology and Therapeutics, Grace Cancer Drug Center, Roswell Park Cancer Institute, Buffalo, New York 14263, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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