Source:http://linkedlifedata.com/resource/pubmed/id/12406546
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rdf:type | |
lifeskim:mentions |
umls-concept:C0015111,
umls-concept:C0021493,
umls-concept:C0025936,
umls-concept:C0026809,
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umls-concept:C0079058,
umls-concept:C0086418,
umls-concept:C0205171,
umls-concept:C0205263,
umls-concept:C0206243,
umls-concept:C0221198,
umls-concept:C0227843,
umls-concept:C0334094,
umls-concept:C0439831,
umls-concept:C1442162,
umls-concept:C1550718
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pubmed:issue |
1-2
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pubmed:dateCreated |
2002-10-30
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pubmed:abstractText |
In our previous study, uterine endometrial stromal sarcomas and atypical hyperplasias of the endometrial glands were induced in heterozygous p53 deficient mice (p53 (+/-) mice) of the CBA strain given a single dose of N-ethyl-N-nitrosourea (ENU). In order to clarify whether uterine tumors can be induced in transgenic mice carrying a human prototype c-Ha-ras gene (rasH2 mice) that are very susceptible to genotoxic carcinogens, rasH2 mice and their wild-type littermates received an intraperitoneal injection of 120 or 0mg/kg body weight of ENU followed by no further treatment for 22 weeks. Eighteen and 94% of ENU-treated rasH2 mice had uterine endometrial adenocarcinomas and atypical hyperplasias, respectively. Other malignant and benign tumors such as lung alveolar/bronchiolar adenomas and carcinomas, forestomach squamous cell papillomas and carcinomas, splenic hemangiomas/sarcomas, skin papillomas, malignant lymphomas and harderian gland adenomas were also observed in ENU-treated rasH2 mice. The result in the present study suggests that female rasH2 mice are very susceptible to uterine carcinogenesis, providing a useful model for ENU-induced uterine epithelial tumors.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0304-3835
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
188
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
39-46
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:12406546-Adenocarcinoma,
pubmed-meshheading:12406546-Alkylating Agents,
pubmed-meshheading:12406546-Animals,
pubmed-meshheading:12406546-Endometrial Neoplasms,
pubmed-meshheading:12406546-Ethylnitrosourea,
pubmed-meshheading:12406546-Female,
pubmed-meshheading:12406546-Genes, ras,
pubmed-meshheading:12406546-Genetic Predisposition to Disease,
pubmed-meshheading:12406546-Injections, Intraperitoneal,
pubmed-meshheading:12406546-Mice,
pubmed-meshheading:12406546-Mice, Inbred CBA,
pubmed-meshheading:12406546-Mice, Transgenic,
pubmed-meshheading:12406546-Point Mutation
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pubmed:year |
2002
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pubmed:articleTitle |
Rapid induction of uterine endometrial proliferative lesions in transgenic mice carrying a human prototype c-Ha-ras gene (rasH2 mice) given a single intraperitoneal injection of N-ethyl-N-nitrosourea.
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pubmed:affiliation |
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, 183-8509, Tokyo, Japan.
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pubmed:publicationType |
Journal Article
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