Linked Life Data

1240635

Source:http://linkedlifedata.com/resource/pubmed/id/1240635

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1976-4-9
pubmed:abstractText
A new method is described with which the effects of drugs on aggressive behaviour can be compared with their effects on general activity. Two groups of 3 male mice are housed in either half of a macrolon living cage which is divided down the middle by a non-transparent barrier. After 21 days the cage is placed on an activity meter and the dividing wall is removed. The ensuing fighting is scored by an observer and at the same time activity is measured using the activity meter. It was shown that aggression occurred mainly between groups with the dominant members doing most of the fighting. It appeared further that the two parameters measured--aggression and motor activity--respond differentially to the effects of standard psychotropic drugs. By this means it was possible to distinguish between the effects of chlorpromazine, pentobarbitone, chlordiazepoxide and d-amphetamine. In addition it was possible to confirm that an experimental compound, YG 19-256, which in other tests has been shown to inhibit aggressive behaviour without causing general sedation, also has selective anti-aggressive effects in this test. From these results it seems that the intergroup aggression test could well be useful in identifying different classes of psychotropic agents.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0033-3158
pubmed:author
pubmed:issnType
Print
pubmed:day
31
pubmed:volume
45
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
133-8
pubmed:dateRevised
2009-10-27
pubmed:meshHeading
pubmed:year
1975
pubmed:articleTitle
Inter-group aggression in mice: a new method for testing the effects of centrally active drugs.
pubmed:publicationType
Journal Article, Comparative Study