|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
2002-10-29
|
|
pubmed:abstractText |
Hepatic bile salt secretion is an essential function of vertebrate liver. Rat and mouse bile salt export pump (Bsep) are adenosine triphosphate (ATP)-dependent bile salt transporters. Mutations in human BSEP were identified as the cause of progressive familial intrahepatic cholestasis type 2. BSEP protein is highly identical with its rat and mouse orthologs and has not yet been functionally characterized; the effect of BSEP mutations on its function has also not been studied. Therefore, the aim of this study was to functionally characterize human BSEP.
|
|
pubmed:commentsCorrections |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
0016-5085
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
123
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1659-66
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:12404240-ATP-Binding Cassette Transporters,
pubmed-meshheading:12404240-Adenosine Triphosphate,
pubmed-meshheading:12404240-Animals,
pubmed-meshheading:12404240-Baculoviridae,
pubmed-meshheading:12404240-Base Sequence,
pubmed-meshheading:12404240-Bile Acids and Salts,
pubmed-meshheading:12404240-Bile Canaliculi,
pubmed-meshheading:12404240-Biological Transport,
pubmed-meshheading:12404240-Cell Line,
pubmed-meshheading:12404240-Female,
pubmed-meshheading:12404240-Gene Transfer Techniques,
pubmed-meshheading:12404240-Genetic Vectors,
pubmed-meshheading:12404240-Humans,
pubmed-meshheading:12404240-Insects,
pubmed-meshheading:12404240-Kinetics,
pubmed-meshheading:12404240-Liver,
pubmed-meshheading:12404240-Middle Aged,
pubmed-meshheading:12404240-Molecular Sequence Data
|
|
pubmed:year |
2002
|
|
pubmed:articleTitle |
Functional expression of the canalicular bile salt export pump of human liver.
|
|
pubmed:affiliation |
Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, Zurich, Switzerland.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
