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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2002-10-29
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pubmed:abstractText |
Proton pump inhibitors (PPIs) are covalent inhibitors of the gastric H+,K+-adenosine triphosphatase (ATPase) forming disulfide bonds. Recovery of acid secretion after PPI inhibition may be due to de novo synthesis of pump protein and/or disulfide reduction and reactivation of inhibited pump. The half-time of recovery of acid secretion in rats following omeprazole treatment is approximately 15 hours, whereas pump protein half-life is 54 hours. In humans, the half-life of the inhibitory effect on acid secretion is approximately 28 hours for omeprazole and approximately 46 hours for pantoprazole. Whereas all PPIs bind to cysteine 813, pantoprazole additionally binds to cysteine 822, deeper in the membrane domain of TM6. Their different durations of action may reflect different rates of pump reactivation due to differing accessibility of the disulfides to glutathione.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0016-5085
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
123
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1588-97
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12404233-2-Pyridinylmethylsulfinylbenzimidazoles,
pubmed-meshheading:12404233-Animals,
pubmed-meshheading:12404233-Benzimidazoles,
pubmed-meshheading:12404233-Dithiothreitol,
pubmed-meshheading:12404233-Enzyme Activation,
pubmed-meshheading:12404233-Enzyme Inhibitors,
pubmed-meshheading:12404233-Gastric Acid,
pubmed-meshheading:12404233-Glutathione,
pubmed-meshheading:12404233-H(+)-K(+)-Exchanging ATPase,
pubmed-meshheading:12404233-Male,
pubmed-meshheading:12404233-Omeprazole,
pubmed-meshheading:12404233-Proton Pumps,
pubmed-meshheading:12404233-Rats,
pubmed-meshheading:12404233-Rats, Sprague-Dawley,
pubmed-meshheading:12404233-Stomach
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pubmed:year |
2002
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pubmed:articleTitle |
Restoration of acid secretion following treatment with proton pump inhibitors.
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pubmed:affiliation |
Department of Physiology and Medicine, University of California at Los Angeles, and VA Greater Los Angeles Healthcare System, Los Angeles, California, USA.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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