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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2002-10-29
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pubmed:abstractText |
Interleukin (IL)-10 is an anti-inflammatory and immune regulatory cytokine. IL-10-deficient mice (IL-10(-/-)) develop chronic inflammatory bowel disease (IBD), indicating that endogenous IL-10 is a central regulator of the mucosal immune response. Prostaglandins are lipid mediators that may be important mediators of intestinal inflammation. In this study we assessed the role of prostaglandins in the regulation of mucosal inflammation in the IL-10(-/-) mouse model of IBD.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Inflammatory Agents...,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Dinoprostone,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-10,
http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandin-Endoperoxide Synthases,
http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Prostaglandin E,
http://linkedlifedata.com/resource/pubmed/chemical/Sulindac,
http://linkedlifedata.com/resource/pubmed/chemical/sulindac sulfone
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0016-5085
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
123
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1527-42
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:12404228-Animals,
pubmed-meshheading:12404228-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:12404228-Colitis,
pubmed-meshheading:12404228-Colon,
pubmed-meshheading:12404228-Cyclooxygenase Inhibitors,
pubmed-meshheading:12404228-Cytokines,
pubmed-meshheading:12404228-Dinoprostone,
pubmed-meshheading:12404228-Disease Progression,
pubmed-meshheading:12404228-Interferon-gamma,
pubmed-meshheading:12404228-Interleukin-10,
pubmed-meshheading:12404228-Longitudinal Studies,
pubmed-meshheading:12404228-Mice,
pubmed-meshheading:12404228-Mice, Inbred C57BL,
pubmed-meshheading:12404228-Mice, Knockout,
pubmed-meshheading:12404228-Osmolar Concentration,
pubmed-meshheading:12404228-Phenotype,
pubmed-meshheading:12404228-Prostaglandin-Endoperoxide Synthases,
pubmed-meshheading:12404228-Prostaglandins,
pubmed-meshheading:12404228-Receptors, Prostaglandin E,
pubmed-meshheading:12404228-Sulindac,
pubmed-meshheading:12404228-T-Lymphocytes,
pubmed-meshheading:12404228-Time Factors
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pubmed:year |
2002
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pubmed:articleTitle |
Rapid development of colitis in NSAID-treated IL-10-deficient mice.
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pubmed:affiliation |
Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa, USA. daniel-j-berg@uiowa.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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