Linked Life Data

12403983

Source:http://linkedlifedata.com/resource/pubmed/id/12403983

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2002-10-29
pubmed:abstractText
Despite high enthusiasm, early attempts to develop clinical treatments based on animal research with neurotrophins were not successful. Here we survey clinical trials with neurotrophins, compared with neurotrophic factors of other gene families, and delineate the most likely reasons for their failure. We then suggest improved methods for regulated local supply of NTs to specific populations of neurons and discuss future therapeutic procedures evolving from the more detailed knowledge of the signal transduction pathways activated by neurotrophins via their receptors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1097-6256
pubmed:author
pubmed:issnType
Print
pubmed:volume
5 Suppl
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1046-50
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Neurotrophins: from enthusiastic expectations through sobering experiences to rational therapeutic approaches.
pubmed:affiliation
Max Planck Institute of Neurobiology, Am Klopferspitz 18a, 82152 Martinsried-München, Germany.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't