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rdf:type |
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lifeskim:mentions |
umls-concept:C0012171,
umls-concept:C0017337,
umls-concept:C0086860,
umls-concept:C0178602,
umls-concept:C0205214,
umls-concept:C0332120,
umls-concept:C0442821,
umls-concept:C0489488,
umls-concept:C0596690,
umls-concept:C1158917,
umls-concept:C1280500,
umls-concept:C1704675,
umls-concept:C1882417,
umls-concept:C2603343
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pubmed:issue |
18
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pubmed:dateCreated |
2002-10-29
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pubmed:abstractText |
Gene-nutrient interactions affecting high-density lipoprotein cholesterol (HDL-C) concentrations may contribute to the interindividual variability of the cardiovascular disease risk associated with dietary fat intake. Hepatic lipase (HL) is a key determinant of HDL metabolism. Four polymorphisms in linkage disequilibrium have been identified in the HL gene (LIPC), defining what is known as the -514T allele. This allele has been associated with decreased HL activity and increased HDL-C concentrations. However, the effect is variable among populations.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1524-4539
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
29
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pubmed:volume |
106
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2315-21
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:12403660-Adult,
pubmed-meshheading:12403660-Aged,
pubmed-meshheading:12403660-Alleles,
pubmed-meshheading:12403660-Cardiovascular Diseases,
pubmed-meshheading:12403660-Cholesterol, HDL,
pubmed-meshheading:12403660-Cohort Studies,
pubmed-meshheading:12403660-Demography,
pubmed-meshheading:12403660-Dietary Fats,
pubmed-meshheading:12403660-Energy Metabolism,
pubmed-meshheading:12403660-Female,
pubmed-meshheading:12403660-Genetic Predisposition to Disease,
pubmed-meshheading:12403660-Genotype,
pubmed-meshheading:12403660-Humans,
pubmed-meshheading:12403660-Lipase,
pubmed-meshheading:12403660-Liver,
pubmed-meshheading:12403660-Male,
pubmed-meshheading:12403660-Middle Aged,
pubmed-meshheading:12403660-Point Mutation,
pubmed-meshheading:12403660-Polymorphism, Genetic,
pubmed-meshheading:12403660-Promoter Regions, Genetic,
pubmed-meshheading:12403660-Regression Analysis,
pubmed-meshheading:12403660-Risk
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pubmed:year |
2002
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pubmed:articleTitle |
Dietary fat intake determines the effect of a common polymorphism in the hepatic lipase gene promoter on high-density lipoprotein metabolism: evidence of a strong dose effect in this gene-nutrient interaction in the Framingham Study.
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pubmed:affiliation |
Nutrition and Genomics Laboratory, Jean Mayer-US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Mass 02111, USA. ordovas@hnrc.tufts.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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