Source:http://linkedlifedata.com/resource/pubmed/id/12403352
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1-3
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pubmed:dateCreated |
2002-10-29
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pubmed:abstractText |
Technologies for transfer of exogenous genes into primary T cells have been limited until recently. The introduction of new approaches for gene transfer via different viral vectors has expanded the options for genetic manipulation of primary T cells and has provided powerful tools for studies of T cell activation and differentiation. We provide a brief overview of the systems currently available and contrast the advantages and disadvantages of each. We also describe a new transgenic model that enables highly efficient gene delivery into primary T cells by nonreplicating adenoviral vectors.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0257-277X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
131-41
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pubmed:dateRevised |
2011-7-1
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pubmed:meshHeading |
pubmed-meshheading:12403352-Adenoviridae,
pubmed-meshheading:12403352-Animals,
pubmed-meshheading:12403352-Antigens, CD4,
pubmed-meshheading:12403352-Dependovirus,
pubmed-meshheading:12403352-Gene Transfer Techniques,
pubmed-meshheading:12403352-Genes, Reporter,
pubmed-meshheading:12403352-Genetic Vectors,
pubmed-meshheading:12403352-Humans,
pubmed-meshheading:12403352-Lentivirus,
pubmed-meshheading:12403352-Mice,
pubmed-meshheading:12403352-Mice, Transgenic,
pubmed-meshheading:12403352-Receptors, Virus,
pubmed-meshheading:12403352-T-Lymphocytes,
pubmed-meshheading:12403352-Transduction, Genetic
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pubmed:year |
2002
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pubmed:articleTitle |
Gene delivery into primary T cells: overview and characterization of a transgenic model for efficient adenoviral transduction.
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pubmed:affiliation |
Department of Pathology, University of Alabama at Birmingham, 35233-2170, USA.
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pubmed:publicationType |
Journal Article,
Review
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